Project Grant R35GM163892
- The National Institute of General Medical Sciences, a division of the Department of Health and Human Services, awarded Cornell University $390,966 on June 1, 2026, as a Project Grant (CFDA 93.859, Biomedical Research and Research Training) to support research on the roles of the epitranscriptome in tailoring gene expression systems. The recipient will uncover the chemical structure, modifying enzymes, and functions of unique tRNA modifications across various organisms, and investigate how...
- The National Institute of General Medical Sciences (NIGMS) awarded Cornell University $425,552 on July 10, 2026, under the Biomedical Research and Research Training program (CFDA 93.859, Assistance Listing Project Grant R35GM165881) to conduct research on the molecular mechanisms of epigenetic centromere inheritance. The research will elucidate how the histone H3 variant CENP-A—which defines centromere identity—is stably inherited across animal generations through a mechanism that remains...
- The National Institute of General Medical Sciences awarded Cornell University $482,612 in Project Grant R01GM166347 effective July 1, 2026, to support computational and experimental analysis of regulatory syntax governing gene transcription initiation. The research develops and applies machine learning models to identify and interpret DNA sequence motifs and their organizational patterns that control how transcription factors, general transcription factors, and repressors direct RNA polymerase...
- The National Institute of General Medical Sciences awarded Cornell University $415,686 on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to study cellular and molecular mechanisms governing stem cell resilience. The research uses freshwater planarians as a model organism to identify conserved mechanisms by which stem cells resist deterioration and overcome genotoxic stress. Over the five-year performance period ending April 30, 2031, the work pursues...
- The National Institute of General Medical Sciences awarded Cornell University $424,158 on July 21, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate the molecular mechanisms of the Kumgang/MI-2 chromatin remodeling complex and its role in transcriptional fidelity. The research will characterize how tissue-specific zinc finger proteins (ZFPs) interact with the chromatin remodeler MI-2 to repress inappropriate gene transcription. The project will...
- The National Institute of General Medical Sciences awarded Cornell University $404,864 on May 22, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to support quantitative analysis of membrane contact site biology in autophagy. The research investigates the mechanisms and regulation of autophagosome biogenesis—the formation of double-membrane organelles central to cellular degradation and homeostasis—with the goal of developing a general, quantitative, and...
- The National Institute of General Medical Sciences awarded Cornell University $423,195 on March 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to characterize the molecular basis of gene-by-environment interactions within and between species, with particular focus on how gene-by-environment mechanisms originate and diversify across butterfly species. The research program investigates tissue- and stage-specific gene regulatory networks activated by the...
- The National Institute of General Medical Sciences awarded Cornell University $118,457 on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate the structural and evolutionary mechanisms of ribonucleotide reductases and squalene cyclases using synthetic chemistry, biochemistry, structural biology, and phylogenetic analysis. This is a K99/R00 mentored career transition award (Project Grant K99GM166683). In the K99 mentored phase, the investigator...
- The National Institute of General Medical Sciences awarded Cornell University $258,713 on July 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to conduct research on membrane editing and phospholipid homeostasis mechanisms in eukaryotic cells. The research investigates how cells regulate biosynthesis and selective transport of phospholipids to establish and maintain correct phospholipid composition across organelle membranes. The work focuses on phosphatidic...
- The National Institute of General Medical Sciences awarded Cornell University $760,645 on September 15, 2025, under the Biomedical Research and Research Training program (CFDA 93.859) to develop algorithms for quantitative recovery of biomolecular structural ensembles from cryo-EM data. The funded research addresses protein conformational change by developing methods to quantitatively recover the probabilities of protein conformational states from cryogenic-sample electron microscopy...
The National Institute of General Medical Sciences awarded Cornell University $277,649 on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate how DNA topology, R-loop formation, and transcriptional-replicational conflicts regulate gene expression and genome stability. The research employs in vitro and in vivo techniques—biochemical, single-molecule, and genomics methods—to elucidate the mechanistic interplay between DNA torsional stress generated during transcription, co-transcriptional R-loop formation and dissolution, and the dynamics of concurrent transcription-replication encounters. The work addresses how motor proteins such as RNA polymerase couple rotation with DNA translocation, generating supercoiling that impacts gene expression, DNA replication, genome stability, and three-dimensional genome organization. The anticipated findings will clarify unresolved questions in the field and identify novel therapeutic targets, particularly for cancer treatment. Performance is located in New York. The award period runs through March 31, 2031. Cornell University's Office of Sponsored Programs administers the grant as the recipient organization.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $277.6k | 7/22/26 |