Project Grant K99GM166683
- The National Institute of General Medical Sciences awarded Weill Medical College of Cornell University $118,751 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate the molecular basis and physiological impact of mRNA 5' nucleotide expansion. The award funds research defining how mRNA 5' expansion—a previously unrecognized transcriptional phenomenon in which additional A and U nucleotides are incorporated near transcript 5' ends in a...
- The National Institute of General Medical Sciences awarded Cornell University $424,158 on July 21, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate the molecular mechanisms of the Kumgang/MI-2 chromatin remodeling complex and its role in transcriptional fidelity. The research will characterize how tissue-specific zinc finger proteins (ZFPs) interact with the chromatin remodeler MI-2 to repress inappropriate gene transcription. The project will...
- The National Institute of General Medical Sciences, a division of the Department of Health and Human Services, awarded Cornell University $390,966 on June 1, 2026, as a Project Grant (CFDA 93.859, Biomedical Research and Research Training) to support research on the roles of the epitranscriptome in tailoring gene expression systems. The recipient will uncover the chemical structure, modifying enzymes, and functions of unique tRNA modifications across various organisms, and investigate how...
- The National Institute of General Medical Sciences awarded Cornell University $375,154 on June 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to uncover the structure and function of understudied membrane proteins implicated in human disease. The research employs C. elegans as a model organism to systematically examine protein structure, interactome, expression patterns, and associated animal behavior. Over the five-year performance period (through February...
- The National Institute of General Medical Sciences awarded Cornell University $277,649 on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate how DNA topology, R-loop formation, and transcriptional-replicational conflicts regulate gene expression and genome stability. The research employs in vitro and in vivo techniques—biochemical, single-molecule, and genomics methods—to elucidate the mechanistic interplay between DNA torsional stress...
- The National Institute of General Medical Sciences awarded Cornell University $760,645 on September 15, 2025, under the Biomedical Research and Research Training program (CFDA 93.859) to develop algorithms for quantitative recovery of biomolecular structural ensembles from cryo-EM data. The funded research addresses protein conformational change by developing methods to quantitatively recover the probabilities of protein conformational states from cryogenic-sample electron microscopy...
- The National Institute of General Medical Sciences awarded Cornell University $258,713 on July 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to conduct research on membrane editing and phospholipid homeostasis mechanisms in eukaryotic cells. The research investigates how cells regulate biosynthesis and selective transport of phospholipids to establish and maintain correct phospholipid composition across organelle membranes. The work focuses on phosphatidic...
- The National Institute of General Medical Sciences awarded New York University $125,000 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to support a K99/R00 project investigating mitonuclear regulation in Caenorhabditis elegans. The research aims to determine how interactions between mitochondrial and nuclear genomes regulate gene expression and stress responses across tissues. Using natural mitochondrial variation in C. elegans combined with...
- The National Institute of General Medical Sciences, part of the Department of Health and Human Services National Institutes of Health, awarded Cornell University $431,750 on March 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate the drivers of molecular convergence in insect adaptation to cardenolides. The research examines how lineage-specific constraints shape convergent evolution across 30 independent origins of cardenolide-specialization in...
- The National Institute of General Medical Sciences awarded Cornell University $404,864 on May 22, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to support quantitative analysis of membrane contact site biology in autophagy. The research investigates the mechanisms and regulation of autophagosome biogenesis—the formation of double-membrane organelles central to cellular degradation and homeostasis—with the goal of developing a general, quantitative, and...
The National Institute of General Medical Sciences awarded Cornell University $118,457 on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate the structural and evolutionary mechanisms of ribonucleotide reductases and squalene cyclases using synthetic chemistry, biochemistry, structural biology, and phylogenetic analysis. This is a K99/R00 mentored career transition award (Project Grant K99GM166683). In the K99 mentored phase, the investigator will experimentally characterize a recently discovered subclass of Class O ribonucleotide reductase and establish its evolutionary significance, developing further training in biochemistry, structural biology, and phylogenetic analysis. In the independent R00 phase, the research extends to squalene cyclases to establish their sequence-mechanism-product relationships and uncover new catalytic diversification strategies. Both enzyme families are targets for understanding evolutionary divergence in enzymatic mechanisms with implications for human health: ribonucleotide reductases are essential for DNA synthesis and represent orthogonal drug targets; squalene cyclases catalyze complex polycyclic triterpene synthesis with pharmacological relevance. Work is performed in Ithaca, New York. The award period runs through July 31, 2028.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $118.5k | 7/28/26 |