Project Grant K99GM163015
- The National Institute of General Medical Sciences awarded The Leland Stanford Junior University $1.924 million on August 5, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate how nuclear mechanical properties regulate cell functions independently of gene expression. The research examines whether and how mechanical properties of the nucleus—including size, stiffness, and integrity—control essential cellular processes such as migration, proliferation,...
- The National Institute of General Medical Sciences awarded The Leland Stanford Junior University $125,000 under the Biomedical Research and Research Training program (CFDA 93.859) on May 1, 2026, to develop membrane-centric proximity labeling approaches for mapping lipid-protein and protein-protein networks in live cells. The work targets transient and context-dependent membrane interactions that remain difficult to study with conventional tools. The recipient will engineer conditionally...
- The National Institute of General Medical Sciences awarded The Leland Stanford Junior University $236,736 on August 9, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop chemically induced proximity methodology for rewiring nucleosome engagement patterns. The project runs through April 30, 2028, with work performed in Palo Alto, California. The funded research applies bivalent molecules that bind and bring together two biomolecules to promote the...
- The National Institute of General Medical Sciences awarded The Leland Stanford Junior University $431,563 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop chemical tools for studies of ion channel function and physiology. The work focuses on creation of small-molecule chemical agents—including modified natural toxins, fluorescence imaging probes, photochemical cross-linking agents, and subtype-specific inhibitors—to enable investigation...
- The National Institute of General Medical Sciences awarded The Leland Stanford Junior University $152,600 for a Project Grant (CFDA 93.859, Biomedical Research and Research Training) on January 18, 2027, to conduct research decoding mechanisms and signaling by an S-acylated isoform of calcineurin. The award funds a fellowship project investigating how S-acylation and calcium/calmodulin signaling coordinate to regulate CNAB1's membrane localization, catalytic activity, and substrate...
- The National Institute of General Medical Sciences awarded The Leland Stanford Junior University $158,696 on February 19, 2027, under the Biomedical Research and Research Training program (CFDA 93.859) to decode the molecular grammar of repressive condensates using spatial-functional screens. The research integrates rational deep variant scanning, a protein language model trained on intrinsically disordered regions (RAVEN), image-enabled cell sorting, and pooled reporter-based functional...
- The National Institute of General Medical Sciences awarded The Leland Stanford Junior University $364,910 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to engineer enzyme-responsive elastin-like polypeptides that direct biomolecular phase behavior for applications in regenerative tissue engineering, controlled drug delivery, and scalable therapeutic biomolecule production. The recipient will develop stimuli-responsive biopolymers triggered by...
- The National Institute of General Medical Sciences awarded The Leland Stanford Junior University $304,000 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop and apply adaptive optical tweezers for probing live cell membrane tension dynamics in health and disease states. The funded research focuses on quantifying physical forces and mechanical properties governing cellular processes, particularly cell membrane tension during mitosis. The...
- The National Institute of General Medical Sciences awarded The Leland Stanford Junior University $285,031 on June 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to support research on the role of ufmylation in ribosome quality control. The research explores how the ubiquitin-fold modifier 1 (UFM1) conjugation system orchestrates ribosome quality control in mammalian cells, focusing on how ufmylation coordinates the disassembly and clearance of stalled...
- The National Institute of General Medical Sciences awarded the University of California, San Diego $125,000 on July 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859, Project Grant K99GM162992). The award funds research into biophysical mechanisms of mechanotransduction and cell morphology, examining how cells respond and adapt to biochemical and physical environmental cues. The project focuses on mechanotransduction signaling in response to substrate material...
The National Institute of General Medical Sciences awarded The Leland Stanford Junior University $125,000 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) for Project Grant K99GM163015, which runs through August 31, 2028. The award funds research into mechanisms of ionic stress sensing and mitigation during mammalian osmoadaptation. The investigator will employ CRISPR base editing screens to define sequence features in the transcription factor NFAT5 that enable detection of ionic strength changes, identify homotypic and heterotypic interactions that drive adaptive gene expression programs, and characterize genes that influence cell growth and survival under ionic stress conditions. Prior postdoctoral work, published in Science Advances in 2025, established that NFAT5's prion-like domain functions as a direct ionic strength sensor, forming biomolecular condensates that recruit transcriptional coactivators. This project extends that discovery to address remaining mechanistic gaps in how specialized tissues like the kidney medulla maintain function despite constant exposure to high osmotic gradients. The work is performed in Palo Alto, California.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $125.0k | 8/25/26 |