Project Grant R35GM166180
- Federal Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded Stanford University a $410,256 Project Grant on September 15, 2025, under the Biomedical Research and Research Training program (CFDA 93.859) to develop generative multiscale models of biomolecular conformational dynamics. The primary deliverable is an integrated research program combining physics-based computational modeling with artificial intelligence techniques to advance conformational sampling...
- Federal Project Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded The Leland Stanford Junior University a $385,000 Project Grant effective March 1, 2026, through December 31, 2030, under the Biomedical Research and Research Training program (CFDA 93.859). This award supports fundamental research to elucidate the physical and chemical principles governing three-dimensional (3D) genome folding in single cells. The investigator will conduct systematic,...
- Federal Project Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded The Leland Stanford Junior University a $125,000 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) effective May 1, 2026, with completion targeted for April 30, 2028. The award supports the development of innovative membrane-centric proximity labeling technologies designed to map lipid-protein and protein-protein interaction networks in living cells. The...
- Federal Project Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded The Leland Stanford Junior University a $894,238 Project Grant on September 8, 2025, under the Biomedical Research and Research Training program (CFDA 93.859) to develop and deploy TRACK-IT (Transposon Accelerated Chromatin Kinetic Imaging Technology), a next-generation live-imaging platform for studying three-dimensional (3D) genome motion. The project, which extends through July 31, 2029,...
- Federal Project Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded The Leland Stanford Junior University a $423,500 Project Grant on March 6, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to support investigator-initiated basic biomedical research. The award, with a completion date of February 28, 2031, funds a five-year research initiative investigating the molecular mechanisms that regulate membrane protein complex...
- Federal Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded Stanford University a $616,000 Project Grant on March 12, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop next-generation proximity labeling (PL) enzymes for enhanced spatial proteomics research. The project, which extends through February 29, 2028, focuses on engineering and optimizing two innovative enzymes—FLEXID and LACCID—to improve the mapping of...
- Federal Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded The Leland Stanford Junior University a Project Grant of $236,736 under the Biomedical Research and Research Training program (CFDA 93.859) for the project "Rewiring Nucleosome Engagement Through Chemically Induced Proximity." The award was obligated on August 9, 2026, with a completion date of April 30, 2028. The research will be conducted at Stanford's Palo Alto, California campus. This...
- Federal Project Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded Stanford University a $152,600 Project Grant (CFDA 93.859, Biomedical Research and Research Training) effective December 1, 2026, through June 30, 2029, to investigate the molecular mechanisms underlying constitutive heterochromatin formation at human centromeres. The research addresses how more than half of the human genome's repetitive sequences, particularly centromeric repeats, are silenced...
- Federal Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded The Leland Stanford Junior University a $1.73M Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) effective July 1, 2026, through June 30, 2030, to develop a multi-resolution open-top light-sheet expansion microscopy system. The project will deliver a high-resolution microscope platform capable of achieving sub-100 nanometer lateral resolution and sub-350...
- Federal Project Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded The Leland Stanford Junior University a Project Grant of $494,796 under the Biomedical Research and Research Training program (CFDA 93.859) on March 1, 2026, with completion scheduled for December 31, 2030. This award supports fundamental research into myosin structure and function with application to inherited familial hypertrophic cardiomyopathy (HCM). The research investigates how...
The National Institute of General Medical Sciences (NIGMS) awarded Stanford University a $304,000 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) effective September 1, 2026, with completion targeted for May 31, 2031. The funded research project, titled "Visualizing the Hidden Physical Cues: Probing Live Cell Membrane Tension Dynamics in Health and Disease," aims to develop and apply adaptive optical tweezers technology to directly measure and characterize cell membrane tension profiles during mitosis in living mouse embryonic stem cells. The research will employ membrane tether assays to non-invasively monitor cortical force dynamics in real-time, providing quantitative biomechanical data that surpass traditional inference methods based on static imaging or disruptive biophysical measurements. The primary deliverables from this award include fundamental discoveries regarding how physical forces and membrane tension govern cellular processes during cell division, with particular emphasis on understanding mechanical imbalances that may contribute to chromosomal instability and cancer malignancy. This basic research project directly supports NIGMS's mission to increase understanding of biological processes and establish the foundation for advances in disease diagnosis and treatment. The work will be conducted at Stanford's Palo Alto, California campus and is expected to yield novel mechanistic insights into the relationship between cellular mechanics and genomic stability that may inform future therapeutic interventions.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $304.0k | 7/17/26 |