This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $453,750.00 to President and Fellows of Harvard College, doing business as Harvard Medical School, from April 16, 2025 to January 31, 2030. The award will fund the development of innovative mass spectrometry-based proteomics pipelines to improve throughput, depth, and accuracy of protein abundance, post-translational...
The National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), awarded a $967,980 Project Grant to President and Fellows of Harvard College, doing business as Harvard Medical School. The grant, effective from February 1, 2025 to May 8, 2025, supports research on evolutionary tradeoffs in antibiotic resistance. Key activities include laboratory studies of bacterial evolution, with a focus on understanding resistance...
This federal Project Grant award, provided by the Defense Health Agency under the Military Medical Research and Development program (CFDA 12.420), supports research on the regulation of steroid hormone signaling and lipid metabolism by the tuberous sclerosis complex. The $254,233 award was granted to President and Fellows of Harvard College, specifically the Harvard Medical School, for the performance period of April 1, 2025 to March 31, 2027. This research project aims to advance the...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $125,000.00 to Harvard Medical School to elucidate the molecular mechanisms of selective Golgi remodeling by autophagy and its impact on neuronal homeostasis. The funded research aims to: 1) Elucidate the mechanisms of YIPF3/4-mediated selective Golgi autophagy, 2) Create a 3D super-resolution Golgi protein map to understand...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) provides $224,088 to support research to determine the developmental origin and regulation of adult pluripotent stem cells in the regenerative animal Hofstenia. The key objectives are to: (1) identify the molecular pathway underlying adult pluripotent stem cell formation, (2) define the chromatin landscape enabling pluripotency, and (3)...
This federal Project Grant award, number K99GM154114, was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The $124,999 award will support research by the President and Fellows of Harvard College, doing business as Harvard Medical School, to investigate the mechanisms by which the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway recognizes and degrades misfolded proteins....
This Project Grant award of $665,616 from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) supports the development of a novel micro-capsule technology to enable high-throughput analysis of millions of live cell-cell interactions in parallel. The technology aims to address a major unmet need in screening functional antibodies and peptides, evaluating ligand-receptor specificity, and determining cell adhesion affinities....
This $148,568 federal Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) under CFDA 93.859 Biomedical Research and Research Training Program will support research to elucidate the role of chromatin structures in genomic imprinting. The project, led by Harvard University, aims to investigate the regulatory mechanisms and functional implications of allele-specific chromatin structures in the regulation of the MEST-COPG2 imprinted domain, which is associated with...
The National Institute of General Medical Sciences (NIGMS) awarded a $389,211 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to the University of Massachusetts (UMass) Amherst. The grant, which runs from July 2024 to June 2029, will fund research to investigate the biophysical and molecular mechanisms underlying a novel process of "meso-scale gap closure" in tissues undergoing epithelial-mesenchymal transition. The research aims to...
This Project Grant award for $422,500 from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) supports research by Harvard University to investigate the mechanisms and functions of lipid recycling for cellular metabolism. The key focus areas are: 1) Elucidating the regulatory mechanisms underlying the autophagic lipid degradation pathway known as lipophagy, which is critical for cellular lipid metabolism, and 2) Examining...