This $665,616 federal Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) funds the development of a novel micro-capsule technology to enable high-throughput analysis of cell-cell interactions. The project aims to establish two prototype methods that can screen and map cell interactions at a scale 100-10,000 times greater than existing plate-based or microfluidic approaches, with potential...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training Program (CFDA 93.859), supports the development of novel ion chemistry and instrumentation for the characterization of proteins, nucleic acids, and heterogeneous bio-complexes using tandem mass spectrometry. The $1,463,792 award, effective from May 1, 2024 to April 30, 2029, will fund efforts to extend the utility of mass spectrometry and tandem mass...
This Project Grant award, funded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports mechanistic and structural studies on Endoplasmic Reticulum-Associated Degradation (ERAD), a critical protein homeostasis process. The $124,999 award will fund research to: 1) test the hypothesis that the ubiquitin ligase Hrd1 thins the ER membrane to recognize and degrade misfolded membrane proteins, and 2)...
This $349,625 federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports the development of a novel time-resolved cryo-vitrification technique called "VERITAS" (Vitrification Experiment Resolved in Time After Stimulation). The goal of this project is to enable high-resolution imaging of nanoscale cellular dynamics with millisecond temporal resolution by integrating...
This federal Project Grant award in the amount of $713,352 was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859). The award will fund research to design and develop robust, reliable, and generalizable machine-learning models for peptide deduction from mass spectrometry-based omics experiments. The key objectives are to address critical knowledge gaps in this area, including developing generative...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $350,000 to develop a microfluidic/nanofluidic sample preparation platform to improve protein extraction, purification, and analysis for single-cell and low-input proteomics. The new platform aims to enhance the efficiency and reliability of protein extraction and denaturation, enabling more comprehensive proteome...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859) is focused on developing techniques to increase the throughput, statistical power, and accuracy of protein turnover estimation using heavy water metabolic labeling and liquid chromatography-mass spectrometry (LC-MS). The $387,375 award, which runs from September 2024 to August 2028, aims to pursue two key objectives: 1) employ a new...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) is focused on establishing an innovative chemical proteomic platform to map extracellular proteinaceous cysteines and investigate their potential as drug targets. The $389,995 award to Northwestern University will support research across multiple biological scenarios, including T cell activation, GGT5 genetic knockout, and various chemical...
The National Institute of General Medical Sciences (NIGMS) awarded a $483,990 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to President and Fellows of Harvard College (Harvard Medical School) to support research on evolutionary tradeoffs in antibiotic resistance. The project, which runs from February 1, 2025 to December 31, 2029, will explore several related areas, including the competition and interactions between plasmids and mobile genetic elements, the evolution of...
The National Institute of General Medical Sciences (NIGMS) awarded a $306,860 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to Mixedlcmedia LLC, a small disadvantaged business located in West Newton, MA. The grant, awarded on September 16, 2024 with a completion date of August 31, 2025, will fund the development and evaluation of a commercialization-ready prototype ultra-low flow liquid chromatography (ULF LC) platform. This specialized technology, based...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $453,750.00 to President and Fellows of Harvard College (doing business as Harvard Medical School) to develop innovative proteomics pipelines. The key objectives are to improve the depth, throughput, and accuracy of mass spectrometry-based proteomics workflows, with a focus on enhancing sample preparation and data acquisition processes. The research aims to establish high-throughput platforms for profiling proteomes, post-translational modifications, and cysteine accessibility, leveraging state-of-the-art mass spectrometry technologies. The award period is from April 16, 2025, to January 31, 2030. The developed pipelines are expected to benefit the broader scientific community by providing tools to explore various biological questions more efficiently and effectively.