This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) totaling $453,750.00 will support the development of advanced proteomics pipelines to improve depth, throughput, and accuracy of mass spectrometry-based protein analyses. The research will focus on optimizing sample preparation and data acquisition processes to address challenges in profiling proteomes, post-translational modifications, and...
This federal Project Grant award, with an ID of K99GM154065, was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The $125,000 award, with a performance period from December 18, 2024 to November 30, 2026, aims to support research to determine the high-resolution 3D structure of the ZMYM2-KDM1A-CoREST complex and characterize how this complex mediates transcriptional regulation. The research will...
The National Institute of General Medical Sciences (NIGMS) awarded a $423,750 Project Grant under the Biomedical Research and Research Training Program (CFDA 93.859) to President and Fellows of Harvard College, doing business as Harvard Medical School. The grant, effective from Jul 1, 2024 to May 31, 2029, will support research to characterize the functional and phenotypic effects of protein coding genetic variation. The project aims to develop statistical methods to translate genetic data...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under CFDA Program 93.859 Biomedical Research and Research Training, will support research to understand the regulation and mechanisms of endoplasmic reticulum (ER) proteostasis. The $381,251 award, with a project period from August 1, 2024 to July 31, 2029, will be provided to the University of Iowa to: Establish the principles governing the selection of targets by the ER-associated degradation (ERAD)...
This federal Project Grant award R01GM153805, provided by the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859), aims to develop a novel micro-capsule technology to enable high-throughput analysis of millions of live cell-cell interactions in parallel. The $665,616 award, with a project period from September 17, 2024 to August 31, 2028, will support the establishment and benchmarking of two prototype methods: (1)...
This federal Project Grant award of $440,000 from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports a research program at the Sloan-Kettering Institute for Cancer Research focused on decoding the ubiquitin and autophagy signaling networks involved in proteome homeostasis, an essential cellular process. The research aims to uncover novel aspects of ubiquitin regulation and explore the mechanisms underlying selective...
This Project Grant award from the National Institutes of Health's National Institute of General Medical Sciences provides $227,480.44 to President and Fellows of Harvard College, doing business as Harvard Medical School, to conduct research from May 1, 2021 through September 30, 2022. The research will comprehensively examine condition-specific mRNA isoforms and their properties, as well as cellular factors involved in regulating isoform half-lives on a genome-wide scale under various...
This $433,342 Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) under CFDA Program 93.859 - Biomedical Research and Research Training supports research at Brandeis University to discover the underlying mechanisms by which the endoplasmic reticulum (ER) chaperone GRP94 assists in the folding and secretion of insulin-like growth factor (IGF) proteins. The key objectives are to determine how and under what conditions IGF client proteins are transferred from the BIP...
This Project Grant award for $380,540, awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859), supports research to decipher novel principles of rapid proteostatic control and develop spatiotemporal lysosomal tools. The research aims to define new protein substrates and peptide motifs required for lysosomal delivery, determine the functional impact of methyl-driven lysosomal proteolysis on cellular metabolic...
This $100,620 federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports research to understand the mechanisms that regulate proteasome assembly in eukaryotic systems. The research aims to uncover the mechanisms controlling: (1) proteasome subunit gene expression, (2) assembly dynamics of the proteasome core particle and regulatory particle, and (3) post-translational modifications of the...