Project Grant K99GM160696
- This federal Project Grant award of $401,253 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports research to elucidate novel cyclic nucleotide signaling pathways and their physiological effects in bacteria. The research program will synthesize chemical tools and use in vitro and in cellulo techniques to investigate the effects of 2',3'-cyclic nucleotide monophosphates (2',3'-cNMPs) on bacterial...
- This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), will fund research to characterize the molecular mechanisms and evolution of cyclic diguanylic acid (c-di-GMP) signaling in the antibiotic-producing bacterial genus Streptomyces. The $383,746 award, with a performance period from January 1, 2025 to December 31, 2029, will be executed by Cornell University's Office of Sponsored...
- The National Institute of General Medical Sciences (NIGMS) awarded a 5-year, $433,459 Project Grant under CFDA 93.859 (Biomedical Research and Research Training) to the University of Kansas Center for Research Inc. The grant supports fundamental research to expand the understanding of quorum sensing - a type of cell-cell communication used by bacteria, including many pathogens, to coordinate group behaviors. The research will combine laboratory models with molecular genetic and genomic...
- This federal Project Grant award from the National Institutes of Health (NIH) National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $446,435 to support research on the regulatory mechanisms of pterin-dependent signaling in proteobacterial systems. The project, conducted by Trustees of Indiana University (UEI: YH86RTW2YVJ4), will investigate how the cytoplasmic second messenger cyclic diguanylate monophosphate...
- This federal Project Grant award of $348,963.00 was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The award supports fundamental scientific research to investigate the mechanisms of quorum signal synthesis in gram-negative bacteria, with the goal of establishing molecular determinants for substrate recognition and developing quorum sensing inhibitors as potential anti-virulence compounds. The...
- The National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), awarded a $339,552 Project Grant to the Trustees of the Colorado School of Mines (CSM) on September 1, 2025. The grant supports CSM's research program to investigate the structure-dynamics-function relationships that regulate the biogenesis of protein complexes, with a focus on two families of bacterial proteins - S-layers and microcompartments. The goal is to...
- The federal Project Grant award of $186,354 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), is being used to conduct research on the roles of protein glycosylation in prokaryotes. The project aims to perform quantitative glycoproteomic analyses of the opportunistic bacterial pathogen Pseudomonas aeruginosa during different stages of biofilm formation and in response to antibiotics. Additionally, the...
- This federal Project Grant award of $390,000.00, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research on the structural dynamics of G protein-coupled receptor (GPCR) oligomerization and its impact on cellular localization and signaling. The 5-year award, effective August 1, 2025, will fund investigations into the complexes formed between GPCRs, G proteins, β-arrestins, and GPCR kinases,...
- This federal Project Grant award of $294,060 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research to understand biophysical principles of cellular organization at two scales: bacterial communities and intracellular biomolecular condensates. The research aims to elucidate how bacterial quorum sensing operates in natural environments, including the influence of other species, and to investigate...
- This federal Project Grant award of $360,247, granted by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research to investigate the mechanisms underlying the function and regulation of signaling effectors associated with type III CRISPR-Cas systems in microbes. The research aims to advance the understanding of how these RNA-guided immune systems in bacteria and archaea use cyclic nucleotide second...
The National Institute of General Medical Sciences (NIGMS) awarded a $125,000 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to the University of Washington for the period of Sep 1, 2025 to Aug 31, 2027. This grant supports research to elucidate the molecular coordination between the second messenger signaling pathways of cyclic diguanylate monophosphate (c-di-GMP) and cyclic adenosine monophosphate (cAMP) and their roles in Pseudomonas aeruginosa biofilm formation and dispersion. The research aims to characterize how cAMP influences the enzymatic activity of c-di-GMP cyclases and phosphodiesterases, examine how c-di-GMP impacts key proteins controlling cAMP signaling, and elucidate the coordination of these two signaling pathways during biofilm maturation and dispersion under host-related environmental conditions. The findings are expected to advance the fundamental understanding of bacterial biofilm regulation.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $125.0k | 8/27/25 |