Structural dynamics of gpcr oligomerization: impact on localization and signaling
Active Project Grant Awarded Last action
- Award ID
- R35GM159978
- Recipient
-
The Medical College Of Wisconsin, Inc. UEI E8VWJXMMUQ67
- Awarding agency
-
National Institute of General Medical Sciences
National Institutes of Health, Department of Health and Human Services
- Obligated
- $780,000
Award facts
- Assistance listing
- 93.859 Biomedical Research and Research Training
- Completion date 25% complete
- Place of performance
- Wauwatosa, WI 53226, USA
Award details come from USAspending.gov.
Description
- Abstract
- G protein-coupled receptors (gpcrs) are crucial in cellular signaling, transducing extracellular stimuli into intracellular responses. Predominantly located on the plasma membrane, gpcrs are vital in numerous physiological processes, making them key pharmacological targets. Emerging evidence also indicates roles for some gpcrs in various intracellular compartments, signaling in cooperation with soluble molecules or other cellular pathways. Significant advancements in structural biology have enabled the determination of over 350 gpcr structures in complexes with signaling partners, predominantly with g proteins (~96%), but also with β-arrestins (3%) and gpcr kinases (
Transactions
| Action | Obligated | Date |
|---|---|---|
| Amendment | $390,000 | |
| Original award | $390,000 |
Quick answers
Who received award R35GM159978?
R35GM159978 was awarded to The Medical College Of Wisconsin, Inc. by National Institute of General Medical Sciences (National Institutes of Health) on August 1, 2025.
How much is award R35GM159978 worth?
$780,000 has been obligated on R35GM159978.
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