Project Grant K99GM159039
- The National Institute of General Medical Sciences awarded The Regents of the University of California, San Francisco $551,000 on September 3, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop function-selective modulators of multifunctional hub proteins. The research expands two programs: developing molecular glues to stabilize native protein-protein interactions and establishing technologies to study dynamic protein-interaction networks. The work...
- The National Institute of General Medical Sciences awarded $150,104 to The Regents of the University of California, San Francisco on August 8, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to design de novo allosterically regulated proteins for studying intramolecular signal transduction. The recipient will design helical bundle proteins capable of ligand-triggered small-molecule release, with two specific applications: designing a protein that releases the...
- The National Institute of General Medical Sciences awarded the University of California, Davis $672,980 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859, Assistance Listing program title) to conduct research engineering cell-cell adhesion through intercellular junction mechanisms. The research addresses the design and development of monoclonal antibodies targeting distinct cadherin conformations—strand-swap dimers and X-dimers—to engineer cell-cell...
- The National Science Foundation Division of Molecular and Cellular Biosciences awarded the University of California, San Diego $800,000 on June 15, 2026, under the Biological Sciences program (CFDA 47.074) to systematically identify, functionally characterize, and solve high-resolution structures of RNA tertiary motifs in human cells. The research addresses a significant gap in understanding human gene regulation by using innovative chemical probing technology to discover and visualize...
- The National Institute of General Medical Sciences awarded The Regents of the University of California, San Francisco $2.255 million under the Biomedical Research and Research Training program (CFDA 93.859) on September 1, 2026. The award funds development, application, and dissemination of integrative structure modeling methods for computing structural and spatiotemporal models of biomolecular complexes. The recipient will expand the scope of the open-source Integrative Modeling Platform...
- The National Institute of General Medical Sciences awarded The Regents of the University of California, San Francisco $2.1 million on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to support structural and mechanistic research on AAA+ chaperone proteins and their role in protein disaggregation and homeostasis. The award funds cryo-electron microscopy studies of conserved AAA+ family members, including yeast HSP104, bacterial CLP proteins, human...
- The National Institute of General Medical Sciences awarded the University of California Santa Cruz $425,033 on July 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to map variant histone protein interactions and elucidate the molecular mechanisms governing those interactions through advanced proteomics and structural biology. Over the five-year performance period (July 1, 2026 through April 30, 2031), the principal investigator will use nucleosome...
- The National Institute of General Medical Sciences awarded The Regents of the University of California, San Francisco $562,484 on May 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop next-generation visualization and analysis software for multiscale molecular modeling. The recipient will create cutting-edge software tools that integrate visualizations and analyses of molecular structures and related biological information, including...
- The National Institute of General Medical Sciences (NIGMS) of the Department of Health and Human Services awarded the University of California, Berkeley $287,221 in project grant funding on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859). The award funds research into the molecular dynamics of biomolecules and their interactions, with emphasis on fusing biophysics and machine learning approaches. The work develops rigorous computational models and...
- The National Institute of General Medical Sciences awarded The Regents of the University of California, San Francisco $445,049 on April 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop membrane-inspired lipid nanoparticles for cell-type-specific expression of programmable RNA. The recipient will design novel lipid nanoparticle formulations to achieve precise, scalable delivery of biomolecules to specific cell types, combining bio-inspired...
The National Institute of General Medical Sciences awarded The Regents of the University of California, San Francisco $123,147 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop selective small molecule modulators targeting the interaction between DEAD-box (DDX) helicases and RNA. The project runs through August 31, 2028, with place of performance in San Francisco, California. The funded research advances DDX helicase function and druggability through three coordinated aims. Aim 1 enhances target selectivity by bifunctional molecular design, linking rocaglamide with various drug molecules across different linker lengths and assessing cellular activity through competitive affinity-based proteomic profiling and CRISPR interference to evaluate selectivity across DDX helicases. Aim 2 synthesizes rocaglamide-derived covalent modulators and profiles interacting RNA targets using RNA-seq. Aim 3 applies chemical genetics as a general method for selectively targeting specific DDX helicases by identifying cysteine mutations that preserve function in EIF4A1/2 and DDX3X, constructing stable cell lines expressing these mutations, and synthesizing paired covalent molecular glues to evaluate affinity and target engagement. This is a Project Grant assistance type award obligating $123,147 to UCSF, which operates as a major NIH-intensive research institution performing hypothesis-driven biomedical research across a $1.63 billion portfolio of over 8,400 federal awards.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $123.1k | 8/24/26 |