This $368,110 Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research to study the structures and properties of key enzymatic intermediates involved in oxygenase chemistry. The research aims to develop peptide-based synthetic models that can mimic the active sites and reactivity of non-heme iron and copper oxygenases, which are critical for metabolism, natural product...
The National Institute of General Medical Sciences (NIGMS) awarded a $715,109 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to the University of Illinois to uncover novel heme chemistry in microbial systems. The research aims to establish how divergent bacterial diheme proteins stabilize high-valent bis-FeIV states and utilize these intermediates for site-specific substrate oxidation. Key objectives include addressing outstanding questions related to the...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $502,043 in funding to Brandeis University. The research program aims to investigate how transition metals shape catalysis and allostery in metalloproteins, focusing on two key enzyme superfamilies: viral proteases and SAMHD1 dNTPases. The project will dissect the metal-dependent activities of viral proteases from...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) provides $495,117 to the University of Wisconsin System for a project titled "Accessing the Hidden Biosynthetic Capabilities of Fungi". The project aims to advance natural product discovery from filamentous fungi by: (1) elucidating the products of fungal gene clusters encoding unusual enzymes and chemistries, (2) examining how...
This Project Grant award, with a total funding of $450,313, was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The grant supports research to elucidate the molecular mechanisms that underlie the dynamic behavior of multidomain enzymatic factories known as nonribosomal peptide synthetases (NRPSs). The awardee, The Johns Hopkins University, will leverage nuclear magnetic resonance (NMR)...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) provides $244,450 in funding to Michigan Technological University from July 1, 2025 to June 30, 2030. The award supports research to investigate the catalytic mechanisms, structure-function relationships, and dynamics of two key classes of metalloenzymes - matrix metalloproteinases and 2-oxoglutarate-dependent oxygenases. The...
This Project Grant award of $125,000 from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) aims to achieve two key objectives: Establish the first total syntheses of the bacterial metabolites azetidomonamide A, azetidopyridone, and diazetidomonapyridone, in order to enable the evaluation of their biological functions in quorum-sensing behavior and biofilm formation by Pseudomonas aeruginosa. This research could...
This federal Project Grant award, funded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research to understand the novel enzymatic function of histone H3 as a copper reductase. The $433,125 award, with a project period from July 1, 2025 to April 30, 2030, is provided to the University of California, Los Angeles (UCLA) to conduct structural and functional studies on the copper reductase activity...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) supports the development of efficient and accurate methods for identifying novel natural product small molecules from complex mass spectral datasets. The $275,484 award, which began on Sep 1, 2023 and runs through Aug 31, 2024, will enable the grantee, Chemia Biosciences, Inc., to integrate genome mining with computational metabolomics to...
This $555,000 federal Project Grant awarded by the National Science Foundation's (NSF) Division of Chemistry and Molecular and Cellular Biosciences Division is supporting biophysical studies of metalloenzymes conducted by Professor Brian Hoffman at Northwestern University. The research focuses on investigating the structure and function of multimetallic metalloenzymes, particularly those with Fe4 clusters and Fe3M (M=Fe, Mo) analogues, as well as the active site cofactors of nitrogenase...