This Project Grant award, funded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859), supports research to develop fluorescence lifetime imaging microscopy (FLIM) methods for studying organic reactions and processes. The $1,039,146 award to the University of California, Irvine will be used to characterize reaction intermediates, understand mechanisms, and create predictive models for sustainable aqueous-organic...
This $1,542,569 Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) is funding the development of new copper-catalyzed chemical reactions to enable the efficient and stereoselective synthesis of chiral amine derivatives and ethers, including saturated heterocycles. The research objectives include exploring reactions for propagating chirality, developing new enantioselective syntheses of...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training Program (CFDA 93.859), provides $360,100 to The Regents of the University of California, Berkeley (UC Berkeley) to conduct research on supramolecular catalysis for pharmaceutical applications. The project aims to develop innovative synthetic methods leveraging supramolecular hosts to enable transformations relevant to the production of pharmaceuticals,...
This Project Grant award from the National Institute of General Medical Sciences (CFDA 93.859 - Biomedical Research and Research Training) provides $431,400 to North Dakota State University to develop nickel-based catalysts for alkyne hydrofunctionalization reactions. The research aims to leverage directing groups, such as 2-pyridyl moieties, to enhance the efficiency, regio- and stereo-selectivity of nickel-catalyzed alkyne hydroamination and hydroetherification reactions. The project has three...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training Program (CFDA 93.859), is focused on developing new reactions and reagents to generate enantioenriched organic compounds. The $422,569 award supports research aimed at the concise synthesis of secondary amines, tertiary amines, and vicinal diamines as single stereoisomers. The proposed methods involve the use of bis(amidine) reagents that form chiral...
The National Institute of General Medical Sciences (NIGMS) awarded a $524,400 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to the Scripps Research Institute in La Jolla, CA. The grant funds a 5-year research project focused on developing novel catalytic transformations to expedite the synthesis of structurally complex small molecules for drug discovery and development. The project aims to unlock new reactivity modes with earth-abundant metal...
This $986,486.00 federal Project Grant award was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The primary goal of this 5-year project, awarded on May 6, 2025, is to discover new synthetic strategies and concepts to rapidly prepare biologically important and structurally complex molecules, particularly natural products from the Euphorbiaceae and Thymelaeaceae plant families. The research aims to...
This Project Grant award, valued at $775,000.00 and made by the National Institute of General Medical Sciences (NIGMS), supports research under the Biomedical Research and Research Training Program (CFDA 93.859) to expand the chemical and functional space using boron-nitrogen heterocycles. The key objectives of this 5-year project are to: 1) explore novel reactivity and selectivity in synthetic organic chemistry using boron-containing compounds, and discover new mechanistic principles for...
The National Institute of General Medical Sciences (NIGMS) awarded a Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to the University of Texas at Austin to develop catalytic methods for reductive C-C coupling reactions that are as clean, scalable, and cost-effective as catalytic hydrogenation. The $425,960 award, effective from February 1, 2025 to January 31, 2030, will fund research to advance catalytic hydrogen auto-transfer reactions that enable direct conversion of...
The National Institute of General Medical Sciences (NIGMS) awarded a $1,566,752 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to The University of Texas at San Antonio (UTSA) to develop switchable organometallic catalysts for enabling iterative, site-selective organic synthesis reactions. The goal is to create catalysts that can be "switched" using different wavelengths of light to selectively activate either C(sp2)-X or C(sp3)-X bonds, facilitating the...