This $383,891 Project Grant award from the National Institutes of Health (NIH) National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports research to understand the mechanisms driving cell cycle plasticity and robustness. The principal investigator will use advanced time-lapse microscopy tools to investigate how cells can bypass inhibition of the CDK2 cell cycle regulator by activating alternative CDK4/6 pathways, enabling...
This Project Grant award of $534,160 from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) supports advanced research on the molecular mechanisms underlying intracellular ion transport and genome maintenance. The award to the Sloan-Kettering Institute for Cancer Research in New York will fund a 5-year research program focused on four key areas: Elucidating the mechanisms by which ion transport proteins, such as TMEM175,...
The National Institute of General Medical Sciences (NIGMS) awarded a $440,000 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to the Sloan-Kettering Institute for Cancer Research in New York. The 5-year grant, awarded on February 3, 2025, supports advanced research to decode the ubiquitin and autophagy signaling networks, which are essential cellular processes involved in proteome homeostasis. The research program combines expertise in quantitative mass spectrometry,...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) under CFDA 93.859 Biomedical Research and Research Training Program provides $144,362.00 to The Research Foundation For The State University Of New York to investigate the mechanism of Ess1-mediated regulation of the CTD of RNAP II phase separation. The project will be conducted at the Upstate Medical Center in Syracuse, NY and is expected to be completed by April 30, 2025. This research aims to...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) provides $254,919 to the University of California, San Diego (UCSD) over a 5-year period from February 1, 2025 to January 31, 2030. The award supports research to understand the regulatory mechanisms that ensure accurate transmission of the genome during cell division. Key focus areas include investigating how cells prevent incomplete DNA...
This $584,420 Project Grant, awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research into spatiotemporal mapping and engineering of the "dark proteome" - intrinsically disordered proteins and their functions. The principal objectives of the grant are to: (1) investigate the role of protein disorder in facilitating transport through the nuclear pore complex, including developing...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) provides $421,600 to The Morgridge Institute for Research, Inc. to understand how metabolic conditions influence the behavior of human cells. The key products and services to be delivered under this 5-year award include: Elucidating genetic and environmental contributions to human cell fitness and growth, leveraging innovative tools such as a...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports the development of engineered enzymes that can be activated to perform targeted modifications of cellular proteins. The $1,602,000 award to the Dana-Farber Cancer Institute, Inc. (DFCI) will fund research to design and apply novel autoinhibited enzymes that can toggle between inactive and active conformations in response...
This federal Project Grant award, number K99GM154114, was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The $124,999 award will support research by the President and Fellows of Harvard College, doing business as Harvard Medical School, to investigate the mechanisms by which the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway recognizes and degrades misfolded proteins....
This Project Grant award for $125,000.00, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training (CFDA 93.859) program, supports research to investigate the role of protein N-myristoylation in the DNA damage response (DDR) and its impact on genomic stability. The key objectives of this award are to: 1) Assess the association between N-myristoylation, modulated by NMT1 and NMT2, and DDR pathways, including the impact on DNA...