This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $360,100 to The Regents of the University of California, San Francisco (UCSF) to develop designer proteins that can bind photoacid cofactors. The goal is to use these proteins to study proton transfer dynamics in biological systems. The key products to be delivered include: Computational design of protein scaffolds that...
This $1,000,000 Project Grant award from the National Science Foundation's Biological Sciences (CFDA 47.074) program supports research by the University of California, San Francisco (UCSF) to design, build, and test synthetic signaling systems built from computationally-designed de novo protein components. The goal is to develop stable, tunable, and modular signaling systems capable of precisely controlling biological processes, with applications in biotechnology such as engineered cells for...
The National Science Foundation (NSF) awarded a $740,797 Project Grant under the Biological Sciences federal grant program (CFDA 47.074) to the Regents of the University of California, San Francisco (UCSF) to develop and test new methodologies for the rational design of minimalistic light-switchable single-domain proteins. The goal is to engineer these proteins to bind specifically to target proteins in only one photoswitchable chromophore state, allowing for precise spatial and temporal control...
This Project Grant award from the National Science Foundation (NSF) under the Biological Sciences program (CFDA 47.074) provides $369,297 to San Francisco State University (SFSU) to develop a synthetic transhydrogenation module to enhance the production of valuable chemicals using engineered organisms. The key objectives are to: Elucidate the structural mechanisms underlying the autoregulation of the GltAB-GudB enzyme complex in Bacillus subtilis, which regulates glutamate metabolism and impacts...
The National Science Foundation awarded a $538,838 Project Grant under the Biological Sciences federal grant program (CFDA 47.074) to The Regents of the University of California, San Francisco for research titled "Collaborative Research: Mapping Protein-Membrane Interactions from Molecules to Cell-Level Dynamics." The research will develop multiscale models to map how individual protein structures and compositions interact with and deform cell membranes at varying scales, from...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) under CFDA Program 93.859 Biomedical Research and Research Training provides $385,000 in funding to Colorado State University to elucidate the design principles for synthetic signaling systems that enable precision control of gene expression. The 5-year project aims to develop novel molecular tools and gain fundamental insights into the mechanisms of natural signal transduction. Key focus areas...
The National Institute of General Medical Sciences (NIGMS) awarded a $736,344 Project Grant under CFDA 93.859 Biomedical Research and Research Training to The Regents of the University of California, San Francisco (UCSF) with a project period from February 1, 2025 to April 30, 2025. The grant aims to cultivate a supportive academic environment and strengthen the scientific identity and career pathways for historically underrepresented and marginalized graduate students in biomedical research...
The National Institute of General Medical Sciences (NIGMS) awarded a $360,100 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to The Regents of the University of California, San Francisco (UCSF) to develop and test algorithms for iteratively docking subsets of ultra-large small molecule libraries against molecular targets. The project aims to accelerate ligand discovery by overcoming the computational challenges posed by the rapid expansion of chemical space. The research...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports the development of engineered enzymes that can be activated to perform targeted modifications of cellular proteins. The $1,602,000 award to the Dana-Farber Cancer Institute, Inc. (DFCI) will fund research to design and apply novel autoinhibited enzymes that can toggle between inactive and active conformations in response...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $445,000.00 in funding to the Beckman Research Institute of the City of Hope to conduct research on the role of allostery in the function of G protein-coupled receptors (GPCRs) and trimeric G proteins. The key research objectives include: 1) Dissecting the structural basis of allosteric modulation by the third...