Project Grant K99ES039179
- The National Institute of Environmental Health Sciences awarded The Trustees of Columbia University in the City of New York $942,408 on June 1, 2026, under the Environmental Health program (CFDA 93.113) to develop novel metalloproteomics biomarkers and integrate them into observational and experimental studies to assess the role of metals in aging and brain health outcomes. The award funds development of mass spectrometry technologies to quantify metal-protein interactions, stable isotope...
- The National Institute of Environmental Health Sciences, part of the Department of Health and Human Services National Institutes of Health, awarded $815,546 to Icahn School of Medicine at Mount Sinai on June 22, 2026, under the Environmental Health program (CFDA 93.113) to investigate how early-life chemical exposures affect executive function and brain development across adolescence. The research leverages naturally shed deciduous teeth as biomarkers to measure in utero and early childhood...
- The National Institute of Environmental Health Sciences awarded The Trustees of Columbia University in the City of New York $840,607 on June 22, 2026, under the Environmental Health program (CFDA 93.113) to construct individual-level public water contaminant exposure histories and assess associations between contaminant exposures and cardiovascular disease risk in a nationwide pooled cohort. The project will leverage 93,700 participants from eleven NIH-funded cohorts with densely characterized...
- The National Institute of Environmental Health Sciences awarded Boston University Medical Campus $197,600 on November 1, 2025, under the Environmental Health program (CFDA 93.113) to examine early-life exposure to ferroalloy metal mixtures and adolescent cognition. The research investigates how exposure to neuroactive metals—manganese, lead, chromium, and copper—released through ferroalloy industrial emissions affects neurodevelopment in children and adolescents living near such facilities....
- The National Institute of Environmental Health Sciences awarded $429,000 to the Regents of the University of Michigan on September 2, 2026, to investigate early life toxicant and psychosocial co-exposures and their associations with adolescent and emerging adult mental health, under the Environmental Health program (CFDA 93.113), with performance through September 1, 2028. The research uses the ELEMENT cohort, a longitudinal scientific resource with over 30 years of follow-up and extensive...
- The National Institute of Environmental Health Sciences awarded New York University $10.907 million on September 15, 2025, under the Environmental Health program (CFDA 93.113) to conduct a translational study on the accumulation of micro- and nanoplastic particles in mammalian tissues. The research investigates inter-tissue accumulation of micro- and nanoplastic particles across the lifespan, including the quantified concentration of these particles within systemic tissues, the role of sex, age,...
- The National Institute of Environmental Health Sciences awarded $818,402 to The Trustees of Columbia University in the City of New York on July 2, 2026, under the Environmental Health program (CFDA 93.113) to investigate the association between polycyclic aromatic hydrocarbon (PAH) exposure during reproductive windows of susceptibility and biomarkers of chronic disease risk in midlife women. The research leverages the Columbia Center for Children's Environmental Health Mothers and Newborns...
- The National Institute of Environmental Health Sciences awarded New York University School of Medicine $3.234 million on June 20, 2026, under the Environmental Health program (CFDA 93.113, Assistance Listing R01ES037626) to investigate the molecular mechanisms by which nickel exposure disrupts transcriptional regulation and causes lung disease. The research examines how nickel compounds, prevalent in industrial processes and consumer products including stainless steel and batteries, drive...
- The National Institute of Environmental Health Sciences awarded The University of Texas Southwestern Medical Center $649,193 on April 1, 2026, under the Environmental Health program (CFDA 93.113, Project Grant R01ES038329) to investigate molecular mechanisms of epitranscriptomic dysregulation induced by toxic metals. The research examines how naturally occurring heavy metals—arsenic, cadmium, chromium, and nickel—impact post-transcriptional gene regulation through RNA modifications and...
- The National Institute of Environmental Health Sciences awarded Icahn School of Medicine at Mount Sinai $127,710 on August 1, 2026, under the Environmental Health program (CFDA 93.113) to support a K99 Mentored Research Scientist Development Award (Project Grant K99ES039036) focused on early-life environmental exposures and child neurodevelopment. The award funds career development and research training for a developmental cognitive scientist and environmental epidemiologist transitioning to...
The National Institute of Environmental Health Sciences awarded The Trustees of Columbia University in the City of New York $126,355 on August 4, 2026, under the Environmental Health program (CFDA 93.113) to assess tissue-specific responses to metal exposure in humans through development of a blood-based biomarker framework. The funded research establishes whether two recently developed diagnostic tools—the Organ Age Clock (OrgAnge), which uses organ-specific proteins in plasma to estimate biological aging across 11 organs, and the miRNA-based Tissue Signal (mir-ts) Score, which uses tissue-specific miRNAs in plasma to measure tissue health across 17 tissues—can identify tissues responsive to metal exposure. During the K99 phase, the investigator will examine associations of 12 metals with accelerated organ aging and overall tissue health in five key organs (heart, brain, lung, liver, kidney) across five well-characterized cohorts. The project also assesses single-metal and metal-mixture effects on tissue responses, with the goal of establishing a framework for detecting early, tissue-specific molecular and cellular responses to environmental metal exposure before clinical disease emerges. This blood-based approach addresses the challenge that chronic metal exposures (lead, mercury, and others) selectively target specific tissues and elicit tissue-specific changes long before diseases occur. Work is performed in New York, New York. The award period runs through July 31, 2028. This is a Project Grant, classified as an assistance award.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $126.4k | 8/3/26 |