The University of Rochester was awarded a $1,199,421 Project Grant by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) to address perceived social isolation, a key psychosocial factor associated with increased opioid use and relapse among individuals with opioid use disorder (OUD). The proposed 5-year project will evaluate the efficacy of a telehealth-delivered, evidence-based cognitive-behavioral therapy intervention to decrease...
This federal Project Grant award of $1,594,478, awarded by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), will support a 5-year observational study of craving patterns and digital phenotyping in individuals with opioid use disorder (OUD) initiating medication-based treatment (MOUD). The key objective is to develop clinically-informed digital biomarkers and phenotypes that can predict MOUD outcomes. The study will monitor 300...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $1,826,522.00 to The Medical University of South Carolina to develop and evaluate a digital toolkit to enhance screening, assessment, and referral for intimate partner violence (IPV) and co-occurring mental health conditions among individuals with opioid use disorder (OUD) seeking care at opioid treatment programs. The award includes two phases -...
The National Institute on Drug Abuse (NIDA) awarded Labsys LLC a $643,948 Project Grant under the Drug Use and Addiction Research Programs (CFDA 93.279) to develop a wearable continuous drug monitoring device for opioid use disorders (CDM-MOUD). The objective is to create a low-cost, painless patch that can monitor medication levels in interstitial fluid to provide real-time insights into the effectiveness of opioid use disorder treatment protocols. The initial Phase I research will focus on...
This $2,729,018 federal Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), aims to develop and evaluate a mobile health intervention for individuals with co-occurring opioid use disorder (OUD) and post-traumatic stress disorder (PTSD) during community re-entry after residential treatment. The grant supports a ground-up approach to rigorously develop and evaluate a mobile app with both on-demand (24/7 PTSD-OUD...
This federal Project Grant award of $1,039,420 from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), will fund a comprehensive study to characterize the transcriptomic profiles and causal functions of neuronal ensembles within key brain circuits that underlie the facilitation and disinhibition of alcohol and opioid seeking behaviors. The grant, awarded to the Medical University of South Carolina, will employ innovative techniques such...
This federal Project Grant award from the National Institute on Drug Abuse (NIDA), under the CFDA 93.279 Drug Use and Addiction Research Programs, provides $751,043 to investigate the cellular and molecular mechanisms underlying the complex co-morbidity of opioid use disorder (OUD), major depressive disorder (MDD), and HIV infection in the human brain. The research will use advanced techniques like single nuclei RNA sequencing (snRNA-seq) and single-nucleus assay for transposase-accessible...
The National Institute on Drug Abuse (NIDA) awarded a $264,000 project grant under the Drug Use and Addiction Research Programs (CFDA 93.279) to Innovation Research And Training, Inc. (IRT), a woman-owned small business in Durham, North Carolina. The purpose of this 3-year project is to evaluate an interactive, multimedia, web-based, asynchronous training program called "Substance of Change: Building Assets in Mentees Affected by Substance Misuse" (SOC). The training is designed to...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $400,000 to develop and evaluate a customized version of the "MYTRIALS" integrated remote biomarker capture system to support decentralized clinical trials for substance use disorders (SUDs). The key objectives are to refine the existing MYTRIALS prototype to better meet the needs of SUD decentralized trials, and then conduct a...
This federal Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $390,000.00 to the Regents of the University of Michigan to pilot an innovative digital Contingency Management (CM) intervention for individuals with co-occurring opioid and alcohol use disorders. The study aims to: 1) identify optimal settings and approaches to engage Medicaid beneficiaries in digital CM through Medicaid claims data...