Project Grant K99DA060979

Award Date 5/1/25
Completion Date 4/30/27
Dollars Obligated $174K
Federal Grant Program
93.279
Assistance Type
Project Grant
Place of Performance
Pennsylvania, USA
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This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $118,457 to The Trustees of the University of Pennsylvania to conduct research aimed at elucidating the genetic architecture and underpinnings of chronic pain and identifying potential novel pain medications. The key objectives are to 1) characterize the genetic liability for chronic pain and addiction, 2) estimate the causal effects of brain and...
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This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $173,799 to support a 2-year research project at the University of Pennsylvania focused on understanding the role of the brain's endogenous opioid system in pain and placebo analgesia.

The project aims to investigate the signaling dynamics and function of enkephalinergic neural populations in the ventrolateral periaqueductal gray (VLPAG) and the functional relationship between the VLPAG and the ventral tegmental area (VTA) across pain states. Advanced in vivo imaging techniques and optogenetic neurocircuit manipulation will be used to delineate these circuits and their role in endogenous pain modulation. The findings from this research are expected to provide fundamental knowledge about the brain's endogenous opioid system that can inform the development of safer and more effective chronic pain therapies.

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