This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research to better understand how endogenous opioid systems control the analgesic properties of the central noradrenergic system. The $497,550 award to The Washington University in University City, Missouri, with a project period from July 1, 2024 to June 30, 2029, focuses on investigating the mechanisms by which endogenous opioids inhibit the locus coeruleus noradrenergic system to promote endogenous analgesia, and how chronic neuropathic injury disrupts this system. The research aims to define the role of locus coeruleus mu opioid receptors in pain from neuropathic injury, along projections to the medial prefrontal cortex, and identify non-opioid strategies for inhibiting the locus coeruleus to discover new analgesic targets.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $497.6k | 6/28/24 |