This $135,594 Project Grant award was provided by the National Cancer Institute (NCI) under the Cancer Research Manpower (CFDA 93.398) federal grant program. The award aims to develop novel pharmacological approaches to rewire oncogenic gene expression and induce apoptosis in cancer cells, with a focus on aggressive leukemias driven by mixed-lineage leukemia (MLL) gene translocations. The research will involve organic synthesis, pharmacological assays, chromatin mechanism studies, cellular model...
This Project Grant award from the National Cancer Institute (CFDA 93.398 Cancer Research Manpower) provides $119,172 to The Leland Stanford Junior University to conduct research aimed at "Harnessing Multi-Modal and Multi-Omics Data Integration to Decipher Therapeutic Response in Non-Small Cell Lung Cancer." The key objectives are to: (1) Identify clinically relevant spatial cellular architectures contributing to therapeutic response; (2) Develop an image-based digital cytometer to...
This Project Grant award of $1,102,957 from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) to The Leland Stanford Junior University will fund research to investigate the relationship between cancer and cardiovascular disease. The project aims to: 1) use epidemiological and genetic approaches to map causal links and shared genetic factors between the two disease states; 2) leverage advanced mouse models to prove that cancer can directly promote...
The National Cancer Institute (NCI), under the federal Cancer Research Manpower (CFDA 93.398) grant program, awarded a $337,509 project grant to The Leland Stanford Junior University (Stanford University) to conduct high-throughput measurements of RNA-mediated regulation of gene expression and oncogenesis. The project aims to systematically identify functional effector domains within human RNA-binding proteins (RBPs) and investigate how disruptions in RBP function can lead to cancer through...
This Project Grant award from the National Cancer Institute (CFDA 93.395 - Cancer Treatment Research) provides $931,841 to The Leland Stanford Junior University to develop next-generation immunotherapies for pediatric cancers. The funding will support research to overcome the suppressive tumor microenvironment in pediatric solid tumors, optimize multi-specific CAR T cells, and explore in vivo gene delivery approaches to engineer immune populations without ex vivo manufacturing. This work aims to...
This federal Project Grant award from the National Cancer Institute (NCI), under the Cancer Research Manpower (CFDA 93.398) program, will provide $131,099 to The Leland Stanford Junior University (Stanford University) from July 1, 2025 to June 30, 2027. The award will fund research to investigate the multilevel impacts of obesity-related factors, from molecular to neighborhood levels, on the incidence, aggressiveness, and survival of renal cell carcinoma (RCC). The research aims to unravel the...
This $113,147 federal Project Grant award was provided by the National Cancer Institute (CFDA 93.398 Cancer Research Manpower program) to The Leland Stanford Junior University. The grant will fund a 5-year career development program for Dr. Chris McGinnis to prepare him for an independent research career in cancer immunology, focusing on studying tumor-immune interactions during metastasis. The key objectives are to: 1) Use longitudinal single-cell RNA sequencing to uncover novel mechanisms of...
This Project Grant award from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) supports fundamental research aimed at understanding the biological mechanisms underlying acute myeloid leukemia (AML) development and progression. The $487,973 award to The Leland Stanford Junior University will fund a 5-year project investigating the role of pre-leukemic hematopoietic stem cells (pHSCs) in AML pathogenesis. The research will explore the clonal evolution, kinetics, and cell...
This $958,434 federal Project Grant award from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) supports research by The Leland Stanford Junior University to elucidate the molecular mechanisms of RET kinase regulation in human epidermis and define RET-regulated impacts on the tumor immune microenvironment. The long-term goal is to develop topical selective RET inhibitors for effective therapeutic prevention of cutaneous squamous cell carcinoma (CSCC). The proposed research...
This Project Grant award from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) provides $439,644 to The Leland Stanford Junior University to conduct functional studies on human acute myeloid leukemia (AML) stem cells. The key objectives are to: 1) Investigate the relationship between specific genetic mutations and AML stem cell frequency, disease initiation, and disease maintenance by correcting mutations in primary AML cells and AML-induced pluripotent stem cells (iPSCs);...