Project Grant K99CA312735
- Federal Project Grant Award Summary Yale University received a $192,564 Project Grant from the National Cancer Institute (NCI) under the Cancer Research Manpower program (CFDA 93.398), effective September 1, 2025 through August 31, 2028. The award supports the development of innovative dual-target Protease Targeted Chimera (PROTAC)-based protein degraders designed to overcome therapy resistance in metastatic castration-resistant prostate cancer (MCRPC). The research addresses lineage...
- Federal Project Grant Award Summary Yale University received a $150,104 Project Grant from the National Cancer Institute under the Cancer Research Manpower program (CFDA 93.398), effective January 16, 2026, through August 31, 2028. The award supports research investigating the impact of aberrant 5-methylcytosine (M5C) mRNA modification on translation initiation and cancer development. The project aims to determine how dose-sensitive M5C modifications in 5' untranslated regions (5'-UTRs) regulate...
- Federal Project Grant Award Summary Yale University received a $197,600 Project Grant award from the National Cancer Institute (NCI) under the Cancer Research Manpower program (CFDA 93.398) for the period July 1, 2025 through June 30, 2028. The award supports a research initiative titled "Role of Glycosylated RNAs in Acute Myeloid Leukemia," which investigates the biological mechanisms and functions of glycosylated RNAs (glycoRNAs)—RNA molecules post-transcriptionally modified with...
- Federal Project Grant Award Summary Yale University received a $696,189 Cancer Biology Research (CFDA 93.396) project grant from the National Cancer Institute, awarded April 7, 2026, with completion scheduled for March 31, 2031. The grant funds fundamental research investigating the mechanisms of CD8 T cell differentiation in tumor-draining lymph nodes (TDLNs) to improve outcomes for lung adenocarcinoma patients undergoing PD-1 pathway-targeted immunotherapy. The research employs genetically...
- Federal Grant Award Summary Yale University received a $519,592 Project Grant from the National Cancer Institute under the Cancer Detection and Diagnosis Research program (CFDA 93.394) awarded on June 15, 2026, with a completion date of May 31, 2031. The grant supports research to develop and validate deep learning-derived magnetic resonance imaging (MRI) biomarkers for improved risk stratification and treatment selection in localized prostate cancer. Traditional risk assessment methods...
- Federal Grant Award Summary Yale University received a $100,228 Project Grant from the National Cancer Institute (NCI) under the Cancer Research Manpower program (CFDA 93.398) awarded December 1, 2026, with completion targeted for August 31, 2029. The grant supports research investigating the regulation of membrane-chromatin interactions during mitotic nuclear envelope (NE) assembly and their implications for cancer cell survival. The project addresses fundamental mechanisms by which endoplasmic...
- Federal Grant Award Summary Yale University received a $577,750 Project Grant from the National Cancer Institute under the Cancer Cause and Prevention Research program (CFDA 93.393), effective June 1, 2026 through May 31, 2031. The award funds research to investigate the functional role of the PBAF (polybromo-associated BAF) chromatin remodeling complex in small cell lung cancer (SCLC) development and progression. The project will deliver mechanistic insights into how PBAF...
- Federal Grant Award Summary Yale University received a $610,637 Project Grant award from the National Cancer Institute (NCI) under the Cancer Treatment Research program (CFDA 93.395), effective April 1, 2026 through March 31, 2031. The award funds research and development of a versatile drug delivery platform utilizing bioadhesive and non-adhesive biodegradable nanoparticles engineered for selective locoregional delivery of cytotoxic and immune conditioning agents to treat advanced melanoma. The...
- Federal Grant Award Summary The National Cancer Institute awarded a Project Grant (R21) totaling $410,933 under the Cancer Treatment Research program (CFDA 93.395) to the University of California, San Diego, effective March 18, 2026, with a completion date of February 29, 2028. This exploratory research initiative aims to develop next-generation small interfering RNA (siRNA) therapeutics designed to enhance delivery into metastatic castration-resistant prostate cancer (mCRPC) tumor cells by...
- Federal Grant Award Summary Yale University received a $684,252 Project Grant from the National Cancer Institute under the Cancer Biology Research program (CFDA 93.396) effective June 2, 2026, with completion anticipated by May 31, 2031. This research project investigates the functions and mechanisms of innate lymphoid cells type 2 (ILC2s) in trained immunity—a process by which hematopoietic stem and progenitor cells (HSPCs) develop epigenetic memory following inflammatory stimuli such as...
Yale University received a $142,635 project grant from the National Cancer Institute (NCI) under the Cancer Research Manpower program (CFDA 93.398), awarded June 3, 2026, with completion scheduled for May 31, 2028. The grant supports research into long noncoding RNA (lncRNA) networks that drive lineage plasticity and resistance to androgen receptor (AR)-targeted therapies in metastatic castration-resistant prostate cancer (mCRPC). The research will comprehensively elucidate the functions and molecular mechanisms by which frequently observed lncRNA alterations contribute to therapy resistance, with particular focus on the CRNDE lncRNA as a lead candidate. Preliminary findings indicate that CRNDE deletion promotes a therapy-resistant state through upregulation of PLOD2, a collagen-modifying enzyme that elevates intracellular succinate levels and activates neuroendocrine-like transcriptional programs. The investigator will conduct an unbiased genome-wide CRISPR interference (CRISPRi) screen and mechanistic studies to test the central hypothesis that CRNDE-deficiency drives a PLOD2-dependent plastic and resistant phenotype in prostate cancer cells. The research deliverables will include validation of candidate lncRNAs (RAD21-AS, CRNDE, SNHG15, and PSMG3-AS) identified through screening, characterization of molecular mechanisms linking lncRNA alterations to therapy resistance, and in vitro and in vivo experimental data supporting the biological significance of these findings for understanding AR-targeted therapy resistance in mCRPC.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $27.6k | 6/18/26 | ||
| Not listed | $115.1k | 6/5/26 |