Project Grant R01CA311426
- Federal Project Grant Award Summary Yale University received a $696,189 Cancer Biology Research (CFDA 93.396) project grant from the National Cancer Institute, awarded April 7, 2026, with completion scheduled for March 31, 2031. The grant funds fundamental research investigating the mechanisms of CD8 T cell differentiation in tumor-draining lymph nodes (TDLNs) to improve outcomes for lung adenocarcinoma patients undergoing PD-1 pathway-targeted immunotherapy. The research employs genetically...
- Federal Grant Award Summary The National Cancer Institute awarded Yale University a $478,532 Project Grant under the Cancer Biology Research program (CFDA 93.396) effective September 1, 2025, through August 31, 2027. This research initiative will investigate the biological and clinical significance of spatial immune heterogeneity in non-small cell lung cancer (NSCLC), with particular focus on characterizing how the spatial distribution of tumor-infiltrating lymphocytes (TILs) and tertiary...
- Federal Grant Award Summary Yale University received a $672,371 Project Grant award from the National Cancer Institute (NCI) under the Cancer Detection and Diagnosis Research Program (CFDA 93.394), effective September 1, 2025, through August 31, 2028. The grant funds development of ultra-sensitive mass spectrometry-based immunopeptidomics technology utilizing digital microfluidics to identify tumor-specific antigens (TSAs) for cancer immunotherapy applications. The project addresses current...
- Federal Grant Award Summary Yale University received a $482,312 Project Grant from the National Cancer Institute (NCI) under the Cancer Treatment Research program (CFDA 93.395) effective April 2, 2026, through March 31, 2031. The award supports research to develop a novel therapeutic approach for inactivating regulatory T (Treg) cells through targeted protein degradation as a strategy to enhance cancer immunotherapy efficacy and reduce immune-related adverse events. Building on promising...
- Federal Grant Award Summary Yale University received a $167,771 Project Grant from the National Cancer Institute under the Cancer Treatment Research program (CFDA 93.395) awarded August 1, 2025, with completion targeted for July 31, 2027. The award supports research to elucidate the mechanisms of a novel human-specific immune checkpoint interaction between SIGLEC-7 and VSIG4 proteins. The research will utilize a humanized mouse platform (MISTRG6-A2) to develop in vivo models that investigate how...
- Federal Grant Award Summary Yale University received a $577,750 Project Grant from the National Cancer Institute under the Cancer Cause and Prevention Research program (CFDA 93.393), effective June 1, 2026 through May 31, 2031. The award funds research to investigate the functional role of the PBAF (polybromo-associated BAF) chromatin remodeling complex in small cell lung cancer (SCLC) development and progression. The project will deliver mechanistic insights into how PBAF...
- Federal Grant Award Summary Yale University received a $100,228 Project Grant from the National Cancer Institute (NCI) under the Cancer Research Manpower program (CFDA 93.398) awarded December 1, 2026, with completion targeted for August 31, 2029. The grant supports research investigating the regulation of membrane-chromatin interactions during mitotic nuclear envelope (NE) assembly and their implications for cancer cell survival. The project addresses fundamental mechanisms by which endoplasmic...
- Federal Project Grant Award Summary Yale University received a $197,600 Project Grant award from the National Cancer Institute (NCI) under the Cancer Research Manpower program (CFDA 93.398) for the period July 1, 2025 through June 30, 2028. The award supports a research initiative titled "Role of Glycosylated RNAs in Acute Myeloid Leukemia," which investigates the biological mechanisms and functions of glycosylated RNAs (glycoRNAs)—RNA molecules post-transcriptionally modified with...
- Federal Grant Award Summary Yale University received a $610,637 Project Grant award from the National Cancer Institute (NCI) under the Cancer Treatment Research program (CFDA 93.395), effective April 1, 2026 through March 31, 2031. The award funds research and development of a versatile drug delivery platform utilizing bioadhesive and non-adhesive biodegradable nanoparticles engineered for selective locoregional delivery of cytotoxic and immune conditioning agents to treat advanced melanoma. The...
- Federal Grant Award Summary Yale University received a $130,490 Project Grant from the National Cancer Institute (NCI) under the Cancer Research Manpower program (CFDA 93.398), awarded on June 1, 2026, with a completion date of May 31, 2028. This award supports research and training activities focused on the cellular and molecular mechanisms of early-onset colorectal cancer (EOCRC). The funding addresses the public health concern that while late-onset colorectal cancer incidence has declined...
Yale University received a $684,252 Project Grant from the National Cancer Institute under the Cancer Biology Research program (CFDA 93.396) effective June 2, 2026, with completion anticipated by May 31, 2031. This research project investigates the functions and mechanisms of innate lymphoid cells type 2 (ILC2s) in trained immunity—a process by which hematopoietic stem and progenitor cells (HSPCs) develop epigenetic memory following inflammatory stimuli such as infection or cancer exposure. The research will deliver fundamental scientific knowledge on how ILC2s establish trained immunity and regulate immune responses to subsequent inflammatory challenges, with particular focus on their role in mediating anti-tumor immunity through neutrophil and myeloid cell regulation in the tumor microenvironment. The project will advance understanding of cellular and molecular pathways controlling epigenetic responses in trained immunity through interrogation of ILC2 functions, including their interactions with neutrophils, monocytes, and macrophages in response to various microbial ligands. Research outputs will include characterization of how ILC2s functionally alter myeloid populations and identify protective mechanisms against tumor challenge, contributing to the Cancer Biology Research program's objective of providing fundamental information on cancer mechanisms with applications to prevention, detection, diagnosis, and treatment of neoplastic diseases.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $684.3k | 6/5/26 |