Project Grant K99CA308896
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded a $410,545 Project Grant through the Cancer Treatment Research program (CFDA 93.395) to The Research Foundation for the State University of New York to conduct a two-year research initiative (May 1, 2026 – April 30, 2028) addressing monomethyl auristatin E (MMAE)-induced peripheral neuropathy in antibody-drug conjugate (ADC) cancer therapy. The research focuses on identifying novel signaling pathways and evaluating the...
- Federal Grant Award Summary The National Cancer Institute awarded a $403,686 Project Grant to the University of California, Irvine on March 19, 2026, under the Cancer Treatment Research program (CFDA 93.395) to develop and validate innovative drug-diet combination therapies for advanced cancers. The research deliverables include the establishment of an unbiased, parallel genetic screening platform utilizing syngeneic orthotopic pancreatic ductal adenocarcinoma (PDAC) models to systematically...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded Emory University a $156,500 Project Grant on August 1, 2025, under the Cancer Treatment Research program (CFDA 93.395) to conduct integrated multi-omics research exploring the pathophysiology of cachexia in head and neck squamous cell carcinoma (HNSCC) patients. The two-year project, concluding July 31, 2027, will investigate the systemic biological mechanisms underlying cancer cachexia through comprehensive analysis of...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded The MGH Institute of Health Professions, Inc. a Project Grant of $696,498 under the Cancer Cause and Prevention Research program (CFDA 93.393) to develop and optimize a multicomponent intervention designed to improve functional recovery and participation in life activities among breast cancer survivors. The research, spanning from May 1, 2026, through April 30, 2031, will systematically develop an evidence-based intervention...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded H. Lee Moffitt Cancer Center and Research Institute Hospital, Inc., a Project Grant of $734,942 under the Cancer Cause and Prevention Research program (CFDA 93.393) effective August 1, 2025, through July 31, 2030. This project addresses cardiovascular disease (CVD) risk in breast cancer survivors by generating novel DNA methylation biomarker data from the Pathways Study, a prospective cohort of 4,504 women diagnosed with...
- Federal Project Grant Award Summary The National Cancer Institute awarded The Institute For Cancer Research a $429,162 Project Grant (CFDA 93.395, Cancer Treatment Research program) effective August 1, 2025 through July 31, 2027 to conduct a prospective feasibility study exploring the neuroprotective potential of cannabidiol (CBD) in preventing oxaliplatin-induced peripheral neuropathy in colorectal cancer patients. The research deliverables include: (1) evaluation of the feasibility and...
- Federal Grant Award Summary The National Cancer Institute awarded The Institute For Cancer Research a $186,000 Project Grant under the Cancer Treatment Research program (CFDA 93.395) on June 23, 2025, with a completion date of May 31, 2027. The award supports pilot and feasibility studies for NN-01-195, a novel tumor-targeted Aurora-A kinase (AURKA) inhibitor developed through a drug conjugate approach. The research involves preclinical evaluation of this chimeric compound, which fuses an...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded a $323,860 Project Grant to Sloan-Kettering Institute for Cancer Research under the Cancer Research Manpower program (CFDA 93.398) on August 18, 2025, with completion targeted for April 30, 2028. This award supports research investigating the role of mutagenic DNA repair pathways in cancer cell persistence and acquired drug resistance. The project focuses on understanding how cancer cells under stress from anti-cancer...
- Federal Grant Award Summary The National Cancer Institute awarded a $649,021 Project Grant to the University of Louisville's Office of Research & Innovation on June 12, 2025, under the Cancer Treatment Research program (CFDA 93.395) to develop protective interventions against cisplatin-induced kidney injury and chronic kidney disease progression. The research will be conducted through May 31, 2030, utilizing a novel Repeated Low Dose Cisplatin (RLDC) model that more accurately replicates...
- Federal Project Grant Award Summary New York University received a $427,085 Project Grant from the National Cancer Institute (NCI) under the Cancer Cause and Prevention Research program (CFDA 93.393) awarded on August 7, 2025, with completion targeted for July 31, 2027. The grant funds research investigating the relationship between social determinants of health (SDOH)—including food insecurity, dietary quality, and neighborhood-level socioeconomic factors—and cancer-related fatigue (CRF) in...
The National Cancer Institute (NCI) awarded a Project Grant of $176,256 on May 6, 2026, under the Cancer Research Manpower program (CFDA 93.398) to Adventhealth Orlando to support research examining the relationship between nutrition and chemotherapy-induced peripheral neuropathy (CIPN) in cancer survivors. The primary deliverable is a research initiative that integrates nutritional assessment with proteomics analysis to identify biological mechanisms linking dietary quality to reduced CIPN incidence across multiple cancer types receiving platinum-based chemotherapy. The project, which runs through April 30, 2028, leverages the National Cancer Institute-sponsored Exercise and Nutrition Interventions to Improve Cancer Treatment-Related Outcomes (ENICTO) consortium to characterize how diet may mitigate inflammation and oxidative stress—key drivers of CIPN-related symptoms including tingling, pain, and physical dysfunction. The research project directly addresses a gap identified by the National Institutes of Health Pathways to Prevention workshop regarding the absence of high-quality data on whole-diet interventions for managing chemotherapy side effects. By establishing testable assays of CIPN mechanisms and generating clinical evidence on diet's protective effects, the funded research is expected to facilitate evidence-based nutrition guidelines that improve chemotherapy tolerability and patient survival outcomes across cancer populations.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $176.3k | 5/7/26 |