Project Grant R21CA288925
- The National Cancer Institute (NCI), part of the U.S. Department of Health and Human Services, awarded a $734,942 Project Grant under the Cancer Cause and Prevention Research program (CFDA 93.393) to the H. Lee Moffitt Cancer Center and Research Institute Hospital, Inc. in Tampa, Florida. The project, titled "Aging, DNA Methylation, and Incident Cardiovascular Disease in Breast Cancer Survivors," aims to generate new blood DNA methylation data and conduct research to better...
- The National Cancer Institute (NCI) awarded a $1,396,152 Project Grant under the Cancer Biology Research program (CFDA 93.396) to the University of Chicago. The grant, with a project period from December 5, 2024 to November 30, 2029, aims to examine the role of the BNIP3 gene and mitophagy (the selective degradation of mitochondria) in muscle atrophy during cancer cachexia, which is prevalent in pancreatic ductal adenocarcinoma (PDAC). The research will utilize genetically engineered mouse...
- The National Cancer Institute (CFDA 93.395 - Cancer Treatment Research) has awarded Emory University a Project Grant of $156,500.00 to conduct a comprehensive multi-omics investigation of the pathophysiology of cachexia in head and neck squamous cell carcinoma (HNSCC) patients. The 2-year project, running from August 1, 2025 to July 31, 2027, aims to gain a deeper understanding of the early biological mechanisms driving cachexia, a lethal syndrome affecting up to 80% of advanced cancer patients....
- The National Cancer Institute (CFDA 93.396 - Cancer Biology Research) awarded a $1,625,853 Project Grant to New York University (NYU) on December 13, 2024. The grant will support NYU's research to map and characterize the role of 3D "hubs" - regulatory DNA elements that interact with multiple loci - in the context of T-cell leukemia (T-ALL), early T-cell progenitor leukemia (ETP-ALL), and T-cell lymphoma. The project aims to better define how these 3D chromatin structures are rewired...
- The National Cancer Institute (NCI), part of the U.S. Department of Health and Human Services, awarded a $1,338,648 Project Grant under the Cancer Cause and Prevention Research (CFDA 93.393) program to the University of Pittsburgh. The grant will fund a "Hybrid Type I Cluster Randomized Effectiveness-Implementation Trial of CARES" to address clinically significant levels of depression, pain, and fatigue experienced by over 18 million Americans living with cancer. The project aims to...
- The National Cancer Institute (NCI) awarded a $107,071 Project Grant under the Cancer Cause and Prevention Research program (CFDA 93.393) to Rockefeller University, effective March 1, 2025 through February 28, 2029. The grant supports research to investigate the role of inter-organellar communication, specifically between the endoplasmic reticulum and mitochondria, in metabolic reprogramming and cellular plasticity in colorectal cancer. Key objectives include identifying the molecular mechanisms...
- This federal Project Grant award for $279,411.00 was provided by the National Cancer Institute (NCI) under the Cancer Cause and Prevention Research program (CFDA 93.393). The grant, awarded to the University of Washington on March 17, 2025, will support research to examine epigenetic changes during breast cancer treatment and their association with changes in exercise capacity and cardiac function. The study will leverage samples from the NCI-funded UPBEAT study to quantify DNA methylation as...
- This federal Project Grant award of $606,839.00, provided by the National Cancer Institute (CFDA 93.395 - Cancer Treatment Research), supports research to identify gut microbiota that actively deplete intestinal amino acids and evaluate how they affect the tumor microenvironment and cancer progression. The primary awardee is Weill Medical College of Cornell University, a leading academic medical institution with expertise in biomedical research and translational science. The project aims to...
- This federal Project Grant award from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) provides funding to Weill Medical College of Cornell University to conduct research on the signal transduction mechanisms that regulate the activity of the p70 S6 kinase 1 (S6K1) protein. The primary objectives are to better understand how the mTOR complex 1 (mTORC1) signaling pathway regulates and coordinates cellular processes to promote cancer cell growth, proliferation, migration,...
- The National Cancer Institute (NCI) awarded a $455,111 Project Grant under CFDA 93.393 "Cancer Cause and Prevention Research" to the Sloan-Kettering Institute for Cancer Research in New York. The 2-year grant, awarded on September 5, 2023, will support research to "Leverage the Hidden Genome to Recover the Missing Heritability of Cancer." The project aims to 1) estimate additional heritability that can be explained by the "hidden genome" (regions of unknown...
The National Cancer Institute (NCI), under the Cancer Cause and Prevention Research federal grant program (CFDA 93.393), awarded a $427,085 Project Grant to New York University (NYU) to conduct research on the cross-talk between social determinants of health and the mTOR pathway, and its impact on post-treatment fatigue in prostate cancer patients. The research aims to understand how factors such as dietary adversity, socioeconomic status, and genetic factors influence biological pathways related to the mTOR complex 1, which may contribute to cancer-related fatigue. The project will leverage advanced genomic techniques and is expected to be completed by July 31, 2027. This research is intended to inform the development of targeted fatigue therapies and improve quality of life for prostate cancer survivors.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $427.1k | 8/6/25 |