Project Grant K99CA308829
- The National Cancer Institute awarded The Leland Stanford Junior University $137,266 on July 1, 2026, under the Cancer Research Manpower program (CFDA 93.398) to develop comprehensive profiling methods for T-cell lymphomas and personalized therapeutic interventions. The project encompasses three research aims. Aim 1 develops disease monitoring and clonal evolution assessment in T-cell lymphoma by integrating targeted sequencing of cell-free DNA to detect circulating tumor DNA, viral genomes,...
- The National Cancer Institute awarded The Leland Stanford Junior University $143,278 under the Cancer Research Manpower program (CFDA 93.398) on January 1, 2026, to support research investigating evolutionary antagonism between tumors and lymphocytes. The recipient will conduct analyses of clonal diversity in metastatic cancer cells using viral integration site mapping across nine rounds of in vivo selection, perform single-cell transcriptomics to profile phenotypic diversity in relation to...
- The National Cancer Institute awarded The Leland Stanford Junior University $163,999 on September 1, 2026, under the Cancer Research Manpower program (CFDA 93.398) to develop cost-effective, user-friendly, and high-throughput microfluidic organ-on-a-chip models that recreate the human bone marrow and bone microenvironments to study breast cancer metastasis to bone. The research will investigate how bone-forming osteoblasts and bone endothelial cells facilitate the extravasation and early...
- The National Cancer Institute awarded The Leland Stanford Junior University $100,228 on December 1, 2026, under the Cancer Research Manpower program (CFDA 93.398) to support research into the regulation of early breast cancer invasion by cancer-associated fibroblasts. The award funds research examining how cancer-associated fibroblasts (CAFs) and extracellular matrix remodeling drive the transition from ductal carcinoma in situ (DCIS) to invasive breast cancer (IBC). The recipient will conduct...
- The National Cancer Institute awarded The Leland Stanford Junior University $661,135 on June 1, 2026, under the Cancer Treatment Research program (CFDA 93.395) to support basic and applied research on rewiring oncogenic pathways to induce cell death in chronic lymphocytic leukemia. The funded work, led by investigators Crabtree, Kay, Gray, and Woyach, develops a new class of small molecules called TCIPs (transcriptional/epigenetic chemical inducers of proximity) designed to activate programmed...
- The National Cancer Institute awarded The Leland Stanford Junior University $281,340 under the Cancer Research Manpower program (CFDA 93.398) on May 1, 2026, to operate the Stanford Cancer Research Education Program (SCREP), a fully funded 10-week summer cancer research program for undergraduate trainees. SCREP provides undergraduate students with active engagement in cancer-relevant research within laboratories of the Stanford Cancer Institute, combined with training in cancer research concepts...
- The National Cancer Institute awarded a $1.21 million cooperative agreement to The Leland Stanford Junior University on August 7, 2026, to support research on tumor-immune coevolution during metastatic progression under the Cancer Biology Research program (CFDA 93.396). The research investigates how tumors and lymphocytes undergo reciprocal adaptive evolution throughout metastasis, with focus on mechanisms by which early-stage metastatic tumors exploit immune education within lymph nodes to...
- The National Cancer Institute awarded Dana-Farber Cancer Institute, Inc. $170,394 on July 1, 2026, under the Cancer Research Manpower program (CFDA 93.398) to support postdoctoral research training in cancer epigenetics. The award funds research examining polycomb repressive complexes and chromatin remodeling in neuroendocrine lineage carcinomas, particularly the transformation of conventional prostate adenocarcinoma into small-cell neuroendocrine prostate cancer. The investigator will conduct...
- The National Cancer Institute awarded the Beckman Research Institute of the City of Hope $162,000 on August 11, 2026, under the Cancer Research Manpower program (CFDA 93.398) to develop and pilot a self-directed e-learning delivery model for clinical cancer genomics education. The recipient will convert selected core recorded didactic modules from its established Intensive Course in Clinical Cancer Genomics into a self-directed e-learning course bundle using theoretically grounded...
- The National Cancer Institute, within the Department of Health and Human Services, awarded The Leland Stanford Junior University $606,756 on August 1, 2026, under the Cancer Detection and Diagnosis Research program (CFDA 93.394). The award funds development and validation of foundation model-augmented artificial intelligence tools to enable accurate and efficient image guidance in upright proton therapy for lung cancer treatment. The research will create a vision-language framework for...
The National Cancer Institute awarded The Leland Stanford Junior University $166,968 on August 15, 2026, under the Cancer Research Manpower program (CFDA 93.398) to develop single-molecule multi-omics sequencing methods for spatially resolved epigenetic profiling of extrachromosomal DNA (ecDNA) molecules and to investigate the relationship between ecDNA spatial organization, epigenetic landscape, and transcriptional regulation. The work addresses a technical gap in understanding ecDNA's paradoxical features: its accessibility and high oncogene expression despite preferential clustering at the transcriptionally repressive nuclear periphery. The project will employ these novel technologies in controlled experimental ecDNA models to determine the epigenetic and functional consequences of ecDNA localization at the nuclear periphery and to elucidate how ecDNA establishes a permissive chromatin environment for high-level transcription. Performance occurs in Palo Alto, California through July 31, 2028. The Cancer Research Manpower program supports biomedical training opportunities for individuals pursuing careers in basic, clinical, and prevention research relevant to the National Cancer Program.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $167.0k | 7/28/26 |