This Project Grant award from the National Cancer Institute (CFDA 93.398 Cancer Research Manpower) provides $226,608 to The Leland Stanford Junior University to integrate highly multiplexed immunofluorescence with label-free 2D hyperspectral chemical imaging to investigate the colorectal cancer tumor-invasive front. The primary goals are to: 1) Perform preliminary non-destructive, label-free spatiochemical imaging on normal and colorectal cancer patient biopsies to identify differences in...
This National Cancer Institute (CFDA 93.396 Cancer Biology Research) Project Grant award of $560,297 to the Icahn School of Medicine at Mount Sinai supports research to functionally characterize oncofetal stem cells (ONFSCs) in colorectal cancer (CRC). The key objectives are to: Generate phenotypic transcriptional reporters to track the dynamics of LGR5+ cancer stem cells (CSCs) and ONFSCs, and use these to dissect the functional interplay between these stem cell populations. Employ a multi-omic...
This $2,136,715 Project Grant award from the National Cancer Institute (NCI) under the Cancer Cause and Prevention Research program (CFDA 93.393) is focused on harnessing DNA methylation in peripheral blood to improve colorectal cancer prevention. The primary awardee, President and Fellows of Harvard College through its Harvard T.H. Chan School of Public Health, will lead the research effort. Key sub-awards have been made to Dana-Farber Cancer Institute and Boston University to contribute...
This Cooperative Agreement award from the National Cancer Institute (CFDA 93.394 - Cancer Detection and Diagnosis Research) provides $1,280,475.00 to The Leland Stanford Junior University to develop a novel approach for early detection of colorectal cancer using cell-free DNA (cfDNA) methylation profiles. The key objectives are to: (1) characterize the early-stage colorectal cancer cfDNA methylome landscape, and (2) develop a machine learning model to detect early-stage colorectal cancer from...
This $107,071 Project Grant award from the National Cancer Institute's Cancer Cause and Prevention Research program (CFDA 93.393) supports research by Rockefeller University to investigate the role of inter-organellar communication in metabolic reprogramming of colorectal cancer. The project aims to elucidate the molecular mechanisms by which tumor hypoxia modulates endoplasmic reticulum-mitochondria contact sites, a critical feature of cellular metabolism, and how this impacts colorectal cancer...
This federal Project Grant award from the National Cancer Institute (CFDA 93.398 Cancer Research Manpower) provides $159,183 in funding to The Trustees of the University of Pennsylvania to investigate the role of diet and the enzyme ACSS2 in the metabolic and epigenetic regulation of colorectal cancer. The research aims to determine how the dietary components of fructose and acetate (from fiber metabolism) interact to affect colorectal cancer growth and acetyl-CoA metabolism, as well as identify...
This Project Grant award from the National Cancer Institute (NCI), under the federal Cancer Biology Research program (CFDA 93.396), provides $600,499.00 to The Trustees of Columbia University in the City of New York to conduct research on the role of the bacterium Fusobacterium nucleatum (FN) and the protein Annexin A1 (ANXA1) in the development and progression of colorectal cancer. The 5-year project, beginning on April 1, 2025, aims to investigate the mechanisms by which amyloid-like changes...
The federal Project Grant award F31CA295091 is funded by the National Cancer Institute (NCI), under the Cancer Research Manpower (CFDA 93.398) program. The $119,922 award supports research to investigate the role of the Fanconi Anemia (FA) pathway in driving a chromosomal abnormality called chromothripsis, which is frequently observed in cancer genomes. The research aims to comprehensively identify regions of micronucleated chromosomes undergoing FA pathway processing during mitosis, and to...
This Project Grant award from the National Cancer Institute (CFDA 93.398 - Cancer Research Manpower) provides $162,486 to Weill Medical College of Cornell University to conduct research on the functional consequences of mutations in the ZFP36L2 gene on tumor progression and the tumor immune microenvironment in colorectal cancer. The research aims to delineate how ZFP36L2 regulates the inflammatory secretome of colorectal cancer and assess the impact of ZFP36L2 mutations on the composition and...
This Project Grant award from the National Cancer Institute (CFDA 93.395 - Cancer Treatment Research) provides $205,700.00 to the Sloan-Kettering Institute for Cancer Research to conduct research aimed at overcoming rapid resistance to targeted therapies in colorectal cancer. The key products and services to be delivered under this 2-year award include: Evaluating how intrinsic tumor features modulate the development of resistance to targeted therapies in colorectal cancer through analysis of...
This Project Grant award from the National Cancer Institute (CFDA 93.398 - Cancer Research Manpower) will provide $133,598.00 to The Leland Stanford Junior University to utilize a biobank of patient-derived premalignant colon organoid samples to investigate existing and novel chemoprevention strategies for Familial Adenomatous Polyposis (FAP). The research aims to better understand how signaling and metabolic pathways are altered in premalignant polyps in order to design more targeted and effective treatments for FAP patients. Key research activities include investigating mechanisms of resistance and sensitivity to COX-2 inhibitors, as well as identifying new metabolic pathways driving cell growth in polyps to uncover potential new therapeutic strategies. This 2-year award, running from June 2025 to May 2027, has the potential to uncover novel approaches to improve the effectiveness of chemoprevention for FAP and broader applications in sporadic colorectal cancer prevention.