The Icahn School of Medicine at Mount Sinai (ISMMS) has been awarded a $560,297 Project Grant from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) to conduct research on colorectal cancer (CRC). The project aims to functionally characterize a novel population of cancer stem cells, referred to as "oncofetal stem cells" (ONFSCS), and their role in driving tumor evolution and treatment resistance in CRC. Key activities include developing reporters to track the dynamics of ONFSCS and LGR5+ cancer stem cells, using multi-omic approaches to understand the molecular drivers of the ONFS state, and performing screening to identify compounds that can selectively target ONFSCS. The goal is to establish a foundation for designing effective combination therapies that could have a significant impact on CRC treatment. This 5-year project is set to commence on September 1, 2024.
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