This Project Grant award from the National Cancer Institute (NCI), under the Cancer Cause and Prevention Research program (CFDA 93.393), provides funding of $107,071.00 to Rockefeller University for research on inter-organellar communication and metabolic reprogramming in colorectal cancer. The research aims to understand how tumor hypoxia regulates endoplasmic reticulum-mitochondrial contacts (ERMCS) and their role in metabolic adaptation and survival of colorectal cancer cells. The project will utilize genetic murine models, primary patient organoids, volumetric electron microscopy, and CRISPR screens to investigate the dynamic changes and requirements for organellar interactions and metabolic compartmentalization during colorectal cancer cell fate alterations. The award period runs from March 1, 2025 to February 28, 2029.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $107.1k | 4/14/25 |