This Project Grant award of $586,106 from the National Cancer Institute (CFDA 93.398 - Cancer Research Manpower program) supports a 5-year effort to refine and pilot test a psychosocial intervention for patients with malignant primary central nervous system tumors. The intervention incorporates elements of Acceptance and Commitment Therapy to address unmet supportive care needs and alleviate distress in this patient population. Specifically, the project aims to: 1) refine the intervention...
This NCI Early K99/R00 Project Grant award (CFDA 93.398 Cancer Research Manpower) provides $224,968 to Wake Forest University Health Sciences to refine and test a cognitive behavioral therapy for insomnia (CBT-I) intervention for lung cancer survivors. The goal is to enhance the feasibility, acceptability, and impact of CBT-I on insomnia and co-occurring symptoms like fatigue, pain, anxiety, depression, and respiratory issues. The award supports stakeholder engagement to refine the CBT-I...
This Project Grant award from the National Cancer Institute (CFDA 93.398 Cancer Research Manpower program) provides $191,490 to the University of Kansas Medical Center Research Institute, Inc. to implement and evaluate a clinical workflow for screening and referring cancer patients with employment concerns to existing support resources. The project aims to: 1) conduct a patient-level needs and assets assessment, 2) evaluate implementation determinants at the clinic level, and 3) design and pilot...
The National Cancer Institute (NCI) awarded a $788,589 Project Grant (CFDA 93.398 Cancer Research Manpower) to Children's Hospital Los Angeles (CHLA) on August 15, 2024. The grant supports research to understand how the transcription factor FOXR2 cooperates with ETS transcription factors to drive the formation of diffuse midline gliomas, a devastating type of childhood brain tumor. The research aims to elucidate the role of MAPK signaling in FOXR2-expressing gliomas and test if ETS transcription...
This $169,776 Project Grant award from the National Cancer Institute's (NCI) Cancer Research Manpower program (CFDA 93.398) supports research by the Fred Hutchinson Cancer Center in Seattle, Washington to investigate mechanisms of immunotherapy resistance in prostate cancer bone metastases. The key products and services to be delivered include: Utilizing mouse models and patient bone biopsies to determine if a specific granulocyte subset (CD62LhiCXCR2hi-Gran) mediates immunotherapy resistance...
This Project Grant award from the National Cancer Institute (CFDA 93.398 - Cancer Research Manpower) provides $161,432 to The University of Texas MD Anderson Cancer Center to develop and evaluate a virtual, group-based expressive writing intervention for adolescent and young adult cancer survivors (AYACSS). The overarching goal is to enhance the quality of life and reduce stress among this population, who face multiple psychosocial disparities. The award will fund a 2-year research plan with the...
This federal Project Grant award from the National Cancer Institute (NCI), under the Cancer Research Manpower (CFDA 93.398) program, provides $162,756 to The Regents of the University of California, San Francisco (UCSF) from April 1, 2025 to March 31, 2027. The award aims to validate a transcriptomic biomarker that correlates with aneuploidy and chromosomal instability in meningiomas, a common type of brain tumor. The funded research will also utilize mouse and in-vitro models to define the role...
The National Cancer Institute (NCI) awarded a $512,974 Project Grant under the Cancer Research Manpower (CFDA 93.398) federal grant program to the Sloan-Kettering Institute for Cancer Research, a non-profit cancer research institution located in New York City. The grant, effective August 13, 2024 through July 31, 2029, will fund research to develop advanced predictive models for non-small cell lung cancer (NSCLC) outcomes using a combination of real-world data sources, including tumor genomic...
The National Cancer Institute (NCI) awarded a $1,036,293 Project Grant under the Cancer Research Manpower (CFDA 93.398) federal grant program to the University of California, Los Angeles (UCLA) for their Neuro-Oncology Translational Research Training Program (NOTR-TP). The NOTR-TP is a multidisciplinary translational research program that aims to expand brain tumor research and clinical care by providing training and mentorship to 4 trainees - 1 predoctoral and 3 postdoctoral fellows,...
This $103,948 Project Grant award from the National Cancer Institute (CFDA 93.393 - Cancer Cause and Prevention Research) to the Sloan-Kettering Institute for Cancer Research supports research aimed at elucidating the mechanisms driving T-cell dysfunction within the tumor microenvironment. The research plan includes two main components: Predoctoral research (Aim 1) to investigate how local amino acid availability limits effector function in tumor-infiltrating T-cells, including profiling the...
The National Cancer Institute (NCI) awarded a $140,854 Project Grant under the Cancer Research Manpower (CFDA 93.398) program to the Fred Hutchinson Cancer Center in Seattle, WA. The purpose of this K99/R00 Pathway to Independence Award is to provide research training and support the transition of Dr. Karl Cristie Figuracion, a postdoctoral research fellow, to become an independent scientist focused on interventions to reduce symptom burden, improve quality of life, and enhance return-to-work outcomes for brain tumor survivors. The research plan involves refining a novel 5-session symptom management education intervention called "Symptom Management Education to Living Fully (SELF)" and then testing its feasibility and preliminary efficacy during the R00 phase. The research generated from this award is expected to advance symptom management interventions to improve health outcomes for brain tumor survivors.