Project Grant K99AR085178
- This $636,198 Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), supports research to decipher the roles of age and inflammation in intervertebral disc degeneration and low back pain. The University of Miami will conduct a systematic investigation to quantify how aging and inflammatory conditions impact proteoglycan biosynthesis, a key process regulating...
- The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $584,330 Project Grant under the Arthritis, Musculoskeletal and Skin Diseases Research federal grant program (CFDA 93.846) to Northeast Ohio Medical University (Neomed) to conduct research on the role of mitochondrial DNA leakage in intervertebral disc degeneration and associated inflammation. The project aims to investigate whether oxidative damage to mitochondrial DNA leads to its fragmentation and...
- The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $703,634 Project Grant under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to The Regents of the University of California, San Francisco (UCSF). The grant, awarded on August 15, 2025, will fund a study to develop and validate age-relative measures of biochemical intervertebral disc health. The research aims to discover the age-course of biochemical disc composition,...
- The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $1,136,924 Project Grant under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to the Rector & Visitors of the University of Virginia. The grant, awarded on July 1, 2025, is intended to support research on "Targeting Stage Specific Influxed Monocytes to Treat Acute and Chronic Back Pain". The project aims to use transgenic mouse models and a CCR2 antagonist to...
- The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $198,263 Project Grant under the Arthritis, Musculoskeletal and Skin Diseases Research federal grant program (CFDA 93.846) to the Board of Regents of the University of Nebraska. The research project aims to investigate the role of the protein Mitsugumin 53 (MG53) in preventing muscle atrophy during periods of disuse, which can contribute to age-related sarcopenia and frailty. The research will explore how...
- This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), aims to develop injectable, cell-adhesive, and growth factor-presenting alginate hydrogels to enhance the therapeutic potential of mesenchymal stem cells (MSCs) for intervertebral disc (IVD) repair. The $752,620 award, spanning September 2024 to August 2026, will fund in vitro studies of MSCs...
- This $820,142 Project Grant was awarded by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research (CFDA 93.846) program. The grant aims to investigate the effects of early-life physical inactivity in mice on muscle quality, function, and frailty development in adulthood. Specifically, the research will examine the regulatory aspects of the extracellular matrix, muscle macrophages, and physical...
- This federal Project Grant award of $471,513 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) supports research to investigate the mechanisms underlying neuromuscular diseases where glycosylation is disrupted. The University of Maine System, through its Research & Sponsored Program division, will use a zebrafish model to study how loss of the dolichylphosphate mannose...
- The University of Pennsylvania was awarded a $459,820 Project Grant from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research federal grant program (CFDA 93.846). The grant will support research into the role of mitochondrial respiration and bioenergetic metabolism in the regulation and development of growth plate chondrocytes, which are central to bone formation. The research aims to improve...
- This federal Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), is funding research on the role of HOX-expressing interstitial cells in muscle growth, homeostasis, and regeneration. The $557,357 award, effective from March 14, 2025 through February 28, 2030, will support a University of Wisconsin-Madison research project investigating the ability of a...
This federal Project Grant award of $115,301 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research federal grant program (CFDA 93.846) supports research to investigate the impact of abnormal lipid metabolism on intervertebral disc degeneration in mice. The research will comprehensively assess the mechanical properties of mouse intervertebral discs using in vivo and ex vivo testing systems, after disrupting lipid metabolism through genetic models and high-fat diet interventions. The goal is to understand how abnormal lipid accumulation and metabolism in intervertebral disc cells can lead to early signs of disc degeneration, such as reductions in proteoglycan content, disc height, and mechanical strength. The award has a performance period from September 2025 to August 2027 and is being conducted by the University of Maryland, Baltimore, a prominent academic health sciences institution with extensive expertise in federally funded biomedical research.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $115.3k | 9/4/25 |