Mechanisms of immune protection against respiratory viruses

Active Cooperative Agreement Awarded Last action

Award ID
U19AI181103
Recipient
Awarding agency
Obligated
$7,141,050

Award facts

Assistance listing
93.855 Allergy and Infectious Diseases Research
Completion date 45% complete
Place of performance
St. Louis, MO 63110, USA

Award details come from USAspending.gov.

Description

As the agency reported it.

Abstract
Overall the sars-COV-2 pandemic highlighted the urgent need for better understanding of the mechanisms controlling broadly protective immune responses to rapidly evolving viral pathogens and generating vaccine candidates able to elicit such responses. The washington university cooperative center on human immunology (washu- cchi) application (mechanisms of immune protection against respiratory viruses) proposes a comprehensive research plan towards two main goals: (a) defining the mechanisms of germinal center persistence after vaccination in humans and how germinal center dynamics impact engagement of DE novo b cells and generation of robust CD4+ t cell, long-lived memory b cell, and bone marrow plasma cell responses (project 1); (b) determining the functional caliber of systemic and mucosal immune responses to vaccines and infection and how these impact durability, breadth, and protection (project 2). Three cores will synergize with the two research projects to support the successful completion of the research aims. The administrative core (core a) will manage the consortium, coordinate cross-project activities, and create the structure and environment needed to accomplish washu-cchi's goals. The clinical core (core b) will provide the clinical and statistical expertise to support the design and conduct of the human subjects' research studies conducted under projects 1 and 2. The proteomics core (core c) will capitalize on an array of unique technologies for the interrogation of the circulating antibody protein and b cell repertoires in samples collected under projects 1 and 2. The integrated and synergistic activities across these projects and cores will drive the successful completion of the washu-cchi's ambitious research agenda, enabling achievement of our long-term goals of providing key insights on human immune responses and informing evaluation of new mucosal vaccines targeting the human respiratory tract against existing and emerging respiratory viral pathogens.

Transactions

Action Obligated Date
Amendment $2,380,350
Amendment $2,380,350
Amendment $0
Original award $2,380,350

Subawards

Subrecipient Amount Awarded
University Of Texas At Austin Specific Aims – Core C Specific Aim 1: To determine and analyze the VH:VL repertoire encoded by responding B cell populations after influenza virus and… $251,770
The General Hospital Corporation Specific Aims – Project 1 Specific Aim 1. Determine the cellular and temporal origins of long-lived human MBCs and BMPCs after vaccination. We will study B cell… $194,751
The Regents Of The University Of California Specific Aims – Project 1 Specific Aim 1. Determine the cellular and temporal origins of long-lived human MBCs and BMPCs after vaccination. We will study B cell… $100,000
The Leland Stanford Junior University Specific Aims – Project 2 Aim 1. To define systemic and mucosal Ab responses against SARS-CoV-2 and IAV after vaccination and infection. We hypothesize that… $220,562
Fred Hutchinson Cancer Center Specific Aims – Project 1 Specific Aim 1. Determine the cellular and temporal origins of long-lived human MBCs and BMPCs after vaccination. We will study B cell… $212,244
Fred Hutchinson Cancer Center SCOPE OF WORK Project Title: Mechanisms of Immune Protection Against Respiratory Viruses (Project 1) Project Period: 9/22/2025-6/30/2029 Washington University… $215,216
The General Hospital Corporation SCOPE OF WORK Project Title: Mechanisms of Immune Protection Against Respiratory Viruses (Project 1) Project Period: 9/4/2024-6/30/2029 Washington University… $197,477
The Leland Stanford Junior University SCOPE OF WORK Project Title: Mechanisms of Immune Protection Against Respiratory Viruses (Project 2) Project Period: 9/4/2024-6/30/2029 Washington University… $222,332
The Regents Of The University Of California SCOPE OF WORK Project Title: Mechanisms of Immune Protection Against Respiratory Viruses (Project 1) Project Period: 9/4/2024-6/30/2029 Washington University… $113,485
University Of Texas At Austin SCOPE OF WORK Project Title: Mechanisms of Immune Protection Against Respiratory Viruses (Core C) Project Period: 9/4/2024-6/30/2029 Washington University PI:… $255,298
University Of Texas At Austin SCOPE OF WORK Project Title: Mechanisms of Immune Protection Against Respiratory Viruses (Core C) Project Period: 9/4/2024-6/30/2029 Washington University PI:… $170,579
The Leland Stanford Junior University SCOPE OF WORK Project Title: Mechanisms of Immune Protection Against Respiratory Viruses (Project 2) Project Period: 9/4/2024-6/30/2029 Washington University… $183,815
The General Hospital Corporation SCOPE OF WORK Project Title: Mechanisms of Immune Protection Against Respiratory Viruses (Project 1) Project Period: 9/4/2024-6/30/2029 Washington University… $170,579
The Regents Of The University Of California SCOPE OF WORK Project Title: Mechanisms of Immune Protection Against Respiratory Viruses (Project 1) Project Period: 9/4/2024-6/30/2029 Washington University… $110,291
The Chancellor, Masters, And Scholars Of The University Of Cambridge SCOPE OF WORK Project Title: Mechanisms of Immune Protection Against Respiratory Viruses (Project 2) Project Period: 9/4/2024-6/30/2025 Washington University… $41,229
ST Jude Children's Research Hospital Inc. SCOPE OF WORK Project Title: Mechanisms of Immune Protection Against Respiratory Viruses (Project 1) Project Period: 9/4/2024-6/30/2029 Washington University… $178,171
Show all 16

Quick answers

Who received award U19AI181103?

U19AI181103 was awarded to The Washington University by National Institute of Allergy and Infectious Diseases (National Institutes of Health) on September 4, 2024.

How much is award U19AI181103 worth?

$7,141,050 has been obligated on U19AI181103.

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