Project Grant K99AI190131
- This federal Project Grant award of $2,727,148.00 from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research on the interactions between bacteriophages (phages) and the Salmonella pathogen during oxidative stress. The goal is to characterize the mechanisms by which the Salmonella pathogen senses oxidative stress, and how this leads to the activation of phage-derived enzymes that inhibit the...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $204,347 Project Grant (CFDA 93.855 - Allergy and Infectious Diseases Research) to the University of Vermont & State Agricultural College to study the intracellular colonization strategies of Salmonella enterica serovar Typhimurium within human intestinal epithelial cells and macrophages. The research aims to characterize bacterial and host transcripts during Salmonella infection, distinguish between cytosolic and...
- The University of Utah was awarded a $728,244 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) to conduct research on the molecular mechanisms of Salmonella's type III secretion system. The goal is to develop a better understanding of how this critical virulence mechanism in Gram-negative pathogens, including Salmonella, Shigella, Vibrio, Pseudomonas, Yersinia, and Chlamydia, selects...
- This Project Grant award of $219,122 from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research on the novel regulation of gene expression in the food-borne pathogen Salmonella typhimurium. The research aims to understand how small regulatory RNAs (sRNAs) interact with the 3' untranslated region of the hild mRNA to control its stability, which in turn regulates the Type 3 Secretion System...
- This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $531,245 to Yale University to conduct research on the structure and function of the Salmonella type III secretion sorting platform. Through a multidisciplinary approach, the research aims to investigate the mechanism by which the sorting platform selects and sorts client proteins essential for the pathogenicity of...
- The University of Illinois received a $154,052 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The grant, awarded on August 5, 2025, aims to understand how arginine availability in the gut modulates the pathogenesis of the enteric pathogen Salmonella enterica serovar Typhimurium (STM). Key objectives include: 1) examining the direct utilization of arginine by STM, gut microbiota, and...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $142,492 Project Grant under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855) to The Washington University in Missouri. The grant, titled "High Throughput Identification of Bacteriophages and Their Hosts with Single-Cell Transcriptomics," aims to establish an innovative, high-throughput phage-host pairing tool for rapidly screening complex, naturally occurring microbial...
- This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to understand how the human-adapted Salmonella enterica serovar Typhi (S. Typhi) pathogen activates the Integrated Stress Response (ISR) in host macrophages and how this impacts the innate immune response and infection outcomes. The $173,416 grant, awarded on January 18, 2025, will fund the...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $3,045,291 Project Grant under the Allergy and Infectious Diseases Research (CFDA 93.855) program to The Leland Stanford Junior University. The grant, titled "Molecular Mechanisms of Enterovirus D68 Viral Entry Mediated by the MFSD6 Receptor", aims to study the role of the MFSD6 protein as an entry receptor for Enterovirus D68 (EV-D68) and its importance in disease pathogenesis. The research will focus on...
- The Project Grant award of $197,646 from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855), supports research to enhance the function of bacteriophages (viruses that attack bacteria) as a potential treatment for antimicrobial resistant bacterial infections. The award recipient, the University of California, San Diego (UCSD), will conduct experimental evolution studies to identify genetic...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $131,076 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to The Leland Stanford Junior University. The grant will fund research to systematically understand how evolutionary pressures from the human host and bacteriophages contribute to the genetic diversity of the Salmonella enterica pathogen. Key goals include expanding upon the grantee's established random barcoded transposon sequencing pipeline to study two uncharacterized Salmonella genes with serovar-specific fitness effects during host-associated stress, as well as applying this pipeline to understand the genetic landscape of Salmonella in new directions. The project period runs from August 4, 2025 to July 31, 2027.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $131.1k | 8/13/25 |