Project Grant K99AI192938
- This Project Grant award of $219,122 from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research on the novel regulation of gene expression in the food-borne pathogen Salmonella typhimurium. The research aims to understand how small regulatory RNAs (sRNAs) interact with the 3' untranslated region of the hild mRNA to control its stability, which in turn regulates the Type 3 Secretion System...
- The University of Illinois received a $582,350 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) to conduct research on "Microbiota-Mediated Colonization Resistance to Acinetobacter Baumannii." The research aims to identify key gut resident microbes that can synergize with a complex microbiota to prevent colonization by the multidrug-resistant pathogen Acinetobacter...
- The National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health (NIH), awarded a $585,539 Project Grant under the Allergy and Infectious Diseases Research Program (CFDA 93.855) to the University of Illinois in Chicago. The grant supports research to understand how the pathogen Acinetobacter baumannii, a major public health threat due to its drug resistance, colonizes and persists in the human gut microbiome. The project aims to investigate A....
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $204,347 Project Grant (CFDA 93.855 - Allergy and Infectious Diseases Research) to the University of Vermont & State Agricultural College to study the intracellular colonization strategies of Salmonella enterica serovar Typhimurium within human intestinal epithelial cells and macrophages. The research aims to characterize bacterial and host transcripts during Salmonella infection, distinguish between cytosolic and...
- The University of Utah was awarded a $728,244 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) to conduct research on the molecular mechanisms of Salmonella's type III secretion system. The goal is to develop a better understanding of how this critical virulence mechanism in Gram-negative pathogens, including Salmonella, Shigella, Vibrio, Pseudomonas, Yersinia, and Chlamydia, selects...
- This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to understand how the human-adapted Salmonella enterica serovar Typhi (S. Typhi) pathogen activates the Integrated Stress Response (ISR) in host macrophages and how this impacts the innate immune response and infection outcomes. The $173,416 grant, awarded on January 18, 2025, will fund the...
- This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) provides $168,964 to the University of California, San Diego (UC San Diego) to conduct research on the competition between Salmonella typhimurium (STM) and the gut microbiota. The research aims to gain mechanistic insights into how STM, a leading cause of foodborne illness, antagonizes gut commensals to establish infection in the...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $131,076 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to The Leland Stanford Junior University. The grant will fund research to systematically understand how evolutionary pressures from the human host and bacteriophages contribute to the genetic diversity of the Salmonella enterica pathogen. Key goals include expanding upon the grantee's established random barcoded transposon...
- This Project Grant award, titled "Bacterial Cell Wall Remodeling, Innate Immunity, and Pathogenesis", is funded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The $2,841,668 award will support research conducted by the University of Illinois to investigate how the staphylococcal N-acetyl glucosaminidase B (SagB) enzyme modulates the host immune response to Staphylococcus aureus infections....
- The University of Florida received a $422,125 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) to conduct research on "Salmonella-Mediated Delivery of Francisella Type VI Secretion System Proteins as Antigens to Induce Protective Immunity." The project aims to use a Salmonella-based antigen delivery platform to present Francisella type VI secretion system proteins as...
The University of Illinois received a $154,052 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The grant, awarded on August 5, 2025, aims to understand how arginine availability in the gut modulates the pathogenesis of the enteric pathogen Salmonella enterica serovar Typhimurium (STM). Key objectives include: 1) examining the direct utilization of arginine by STM, gut microbiota, and the host, and 2) assessing how arginine modulates the host immune response. This research seeks to address the significant public health burden caused by STM infections, which affect over 1.35 million people annually in the United States. The project is scheduled for completion on July 31, 2027.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $154.1k | 8/4/25 |