Project Grant R01AI193097
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $430,170 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the University of Pittsburgh. This grant supports research to identify genetic determinants of the neuropathogenesis of enterovirus D68 (EV-D68) using a novel human spinal cord organoid (HSCO) model. The overarching goal is to better understand how recent strains of EV-D68 can cause paralysis, known as acute flaccid...
- The Project Grant award of $190,315 from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) will fund a study to characterize the immune response and identify predictive factors for different clinical presentations of Enterovirus D68 (EV-D68) infection. The study aims to: 1) describe the clinical spectrum and identify clinical factors predictive of EV-D68 disease presentations, and 2) characterize the humoral immune response to...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $131,076 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to The Leland Stanford Junior University. The grant will fund research to systematically understand how evolutionary pressures from the human host and bacteriophages contribute to the genetic diversity of the Salmonella enterica pathogen. Key goals include expanding upon the grantee's established random barcoded transposon...
- This $217,976 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), is for a study to develop an immunocompetent ferret model to investigate the spinal pathology associated with Enterovirus D68 (EV-D68) infection. The study has two main objectives: 1) to examine the longitudinal course of spinal damage in the ferret model, and 2) to delineate the role of spinal cord glial cells in...
- This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $136,988 to the University of Maryland, Baltimore to conduct research on the mechanisms by which the transcription factor TFEB regulates autophagy (the cellular degradation process) during infection by Enterovirus D68 (EV-D68). The research aims to enhance understanding of viral manipulation of autophagy and...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $153,512 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to The Leland Stanford Junior University. The grant will fund research to characterize the renal immune microenvironment in antibody-mediated rejection (ABMR) of kidney transplants in order to develop improved diagnostics and predict treatment response. The research will utilize advanced imaging mass cytometry to profile...
- The University of California, San Diego (UCSD) was awarded a $3,194,992.00 Project Grant by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The grant, awarded on July 16, 2025, supports research to study the roles and regulation of tissue-resident CD8 T cells during a persistent viral infection. The research aims to investigate the mechanisms that allow immune cells to adapt and maintain a long-term...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $466,125 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to New York University School of Medicine. The grant will support research to elucidate the molecular process of orthopox virus entry, including the MPXV and VACV viruses, through a comparative analysis using methods from virology, proteomics, and immunology. The research aims to identify and characterize the interactions...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $489,500 Project Grant under the Allergy and Infectious Diseases Research (CFDA 93.855) program to The Children's Hospital Corporation (doing business as Boston Children's Hospital) on July 24, 2025. The grant will fund structural studies of the full-length nucleocapsid (N) protein of SARS-CoV-2, the virus that causes COVID-19. The goal is to determine the high-resolution structure of the full-length N protein in complex...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $831,235 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the University of Southern California (USC) to explore a key nucleotide synthesis enzyme as a potential target for developing broad-spectrum antiviral therapies. The project, led by Co-PIs Pinghui Feng and Chao Zhang, aims to genetically interrogate the enzyme's role in viral immune evasion and metabolic reprogramming...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $3,045,291 Project Grant under the Allergy and Infectious Diseases Research (CFDA 93.855) program to The Leland Stanford Junior University. The grant, titled "Molecular Mechanisms of Enterovirus D68 Viral Entry Mediated by the MFSD6 Receptor", aims to study the role of the MFSD6 protein as an entry receptor for Enterovirus D68 (EV-D68) and its importance in disease pathogenesis. The research will focus on defining the precise mechanisms by which MFSD6 facilitates EV-D68 entry into cells and gaining high-resolution structural insights into the EV-D68-MFSD6 interaction. The findings could lead to the development of potential antiviral agents or therapeutic interventions against EV-D68 infections, which have been associated with severe respiratory disease and polio-like paralysis. The grant period runs from August 1, 2025 to July 31, 2029.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $3.0m | 8/1/25 |