Project Grant K99AG097973
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded The Regents of the University of California, San Francisco a Project Grant of $1,275,512 under the Aging Research program (CFDA 93.866) for the period June 1, 2025 through May 31, 2027. This award supports biomedical research directed toward understanding how progranulin (PGRN) species contribute to TDP-43 (TAR DNA-binding protein 43) accumulation and proteolysis in age-related neurodegenerative diseases, including...
- Federal Project Grant Award Summary The University of California, San Francisco (UCSF) received a $805,573 Project Grant award from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), effective September 15, 2025, with completion targeted for June 30, 2030. This award supports innovative research investigating the role of N6-methyladenosine (M6A) RNA modifications in Alzheimer's disease and related tauopathies. The research deliverables include comprehensive...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded the University of California, San Francisco a $3.427 million Project Grant under the Aging Research program (CFDA 93.866) on September 15, 2025, for a four-year research initiative examining biological drivers of sex differences in frontotemporal dementia (FTD). The grant supports a comprehensive investigation of why females with FTD demonstrate delayed symptom manifestation despite elevated neurodegenerative burden—a...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded a $681,908 Project Grant to The Regents of the University of California, San Francisco under the Aging Research program (CFDA 93.866) on February 15, 2026, with a completion date of November 30, 2030. This research project, titled "Mechanisms of Protective UFM1-Dependent IRE1 Signaling in Tauopathies," investigates the molecular mechanisms linking the ufmylation pathway to tau proteostasis—the protein homeostasis...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded a $3.15 million Project Grant under the Aging Research program (CFDA 93.866) to The Regents of the University of California, San Francisco, effective June 1, 2025, through February 28, 2030. This research initiative, titled "Aberrant Proteomes in Tauopathy: Revealing Functional Consequences via Multimodal Proteomics," combines mass spectrometry-based proteomics and functional genomics expertise to...
- Federal Project Grant Award Summary The University of California, San Francisco (UCSF) received a $109,084 Project Grant award from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), effective August 15, 2025, with a completion date of May 31, 2030. UCSF's Research in Alzheimer's Disease and Dementia (RADD) Summer Intern Program, developed and led by the Science & Health Education Partnership (SEP), will annually support five public high school students...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded University of California, San Diego $3,138,871 under the Aging Research program (CFDA 93.866) to conduct a comprehensive four-year research project examining human neuropeptide transmitter systems in Alzheimer's disease (AD) pathogenesis. The project, initiated September 15, 2025 and concluding August 31, 2029, will deliver scientific research services focused on defining the complete repertoire of human brain...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded a $3.22 million Project Grant under the Aging Research program (CFDA 93.866) to the University of California, Irvine on September 15, 2025, for research investigating the role of the retrosplenial cortex (RSC) in Alzheimer's disease (AD) pathogenesis. The project, which extends through August 31, 2029, will deliver scientific research products including characterization of neuronal hyperexcitability mechanisms in...
- Federal Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded The Regents of the University of California, San Francisco a Project Grant of $397,560 under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, effective September 23, 2025, with completion targeted for August 31, 2030. The award funds research to elucidate the mechanisms underlying Autoimmune B12 Central Deficiency (ABCD), a newly...
- Federal Grant Award Summary The University of California, San Francisco (UCSF) received a Project Grant of $1,180,687 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), with an award date of August 1, 2025, and completion date of July 31, 2033. This eight-year research initiative focuses on investigating the developmental transition of neural stem cell (NSC)...
The University of California, San Francisco (UCSF) received a $119,785 Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866) awarded March 1, 2026, with a completion date of February 29, 2028. This award funds research investigating the cerebellum's role in behavioral variant frontotemporal dementia (BVFTD), a neurodegenerative disorder characterized by early social cognitive deficits. The project will deliver scientific research outputs examining the relationship between cerebellar structure and function and social cognitive impairment across disease stages, utilizing cross-sectional neuroimaging and clinical data from UCSF's Memory and Aging Center. The grant will produce longitudinal research findings assessing the predictive value of early cerebellar atrophy for later social, cognitive, and psychiatric decline through analysis of data from the multisite ARTFL-LEFFTDS Longitudinal Frontotemporal Lobar Degeneration Study. These research deliverables are designed to advance understanding of the cerebellum's contributions to BVFTD clinical trajectories and social cognition mechanisms, potentially identifying new biomarkers for disease progression and offering insights into brain network dynamics relevant to neurodegenerative disease research supported under the National Institute on Aging's mission to prevent and treat Alzheimer's disease and related dementias.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $119.8k | 2/27/26 |