Project Grant K08NS142575
- This $4,164,187 federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) supports research to develop antigen-directed therapies for autoantibody associated neuroinflammatory diseases. The project aims to facilitate the discovery of autoantibodies directed to cell surface antigens, characterize their specificity, and generate recombinant human...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $423,500 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to The Leland Stanford Junior University (Stanford University) on August 1, 2025. The funding will support a research project titled "Defining Mechanisms of Cognitive Dysfunction in Central Nervous System Autoimmunity" through July 31, 2027. The project aims to evaluate the pathogenic...
- This $198,928 Project Grant was awarded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program. The grant will support research at the University of California, San Francisco to elucidate the cellular mechanisms underlying central nervous system injury and progression in multiple sclerosis. Key objectives include determining the role of astrocyte response,...
- This Project Grant award from the National Institute on Aging (NIA) under CFDA 93.866 - Aging Research will provide $314,000.00 over the period of May 1, 2025 to April 30, 2027 to the University of California, Irvine (UCI) to conduct research on the "Molecular Mechanisms Underlying Reduced Vitamin C Transport Process in Alzheimer's Disease and its Impact on Neuroinflammation". The project aims to investigate the underlying causes for vitamin C deficiency observed in Alzheimer's disease...
- This Project Grant award in the amount of $521,839.00 was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program. The grant supports research at the University of California, San Diego to investigate the molecular mechanisms underlying the activation of microglia, which contribute to oxidative stress and tissue damage in multiple sclerosis (MS)....
- This Project Grant award of $437,875 from the National Institute on Aging's Aging Research program (CFDA 93.866) will fund a 2-year research project at the University of California, San Diego to quantify neurovascular protein lifetimes in the central nervous system under healthy, aging, and Alzheimer's disease conditions. The key objectives are to generate a comprehensive atlas of neurovascular protein lifetimes and identify changes associated with aging and Alzheimer's disease. The project will...
- This federal Project Grant award of $124,404 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) supports research to investigate the role of the human branched-chain aminotransferase enzyme (HBCAT) mitochondrial isoform (HBCATM) in Alzheimer's disease (AD). The study aims to determine how increased HBCATM levels in brain endothelial cells affect brain metabolism and the...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded a Project Grant of $1,375,478 under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to the J. David Gladstone Institutes in California. This grant funding supports a multidisciplinary research program to study the role of neurovascular dysfunction in neurodegeneration, CNS repair, and glial cell biology. Key research activities include in vivo two-photon and super-resolution...
- This federal Project Grant award, issued by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $4,693,249 to the University of California, Los Angeles (UCLA) to conduct research on defining the molecular spectrum of white matter vascular lesions that drive vascular cognitive impairment and dementia (VCID). The project aims to develop a better understanding of...
- This federal Project Grant award of $770,502.00, awarded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research to understand the molecular mechanisms by which collagen IV regulates TGF-beta signaling and its role in cerebral small vessel disease (CSVD). The research will use mouse models to perform intravital imaging of the cerebral vasculature and...
This $198,780 Project Grant, awarded by the National Institute of Neurological Disorders and Stroke (CFDA 93.853 - Extramural Research Programs in the Neurosciences and Neurological Disorders), will fund research conducted by the University of California, San Francisco to investigate the autoimmune mechanisms underlying vitamin B12 deficiency in the central nervous system. The grant aims to elucidate the molecular mechanisms by which autoantibodies inhibit cellular uptake of B12, understand the impacts on myelination and neurological function, and assess the prevalence and effects of this autoimmune B12 deficiency in Alzheimer's disease patients. This 5-year project, with an award date of September 2025, has the potential to lead to substantial improvements in brain health by identifying a modifiable contributor to cognitive dysfunction in neurodegenerative disorders.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $198.8k | 9/22/25 |