Project Grant K99AG095301
- The National Institute on Aging awarded the University of Utah $660,505 on August 1, 2026, under the Aging Research program (CFDA 93.866) to conduct real-world evidence research on antihypertensive intensification versus de-escalation and optimal blood pressure thresholds in older adults, with specific focus on minimizing adverse events including injurious falls, hypotension, acute kidney injury, and electrolyte abnormalities while maximizing brain and heart health outcomes. The research...
- The National Institute on Aging awarded The University of Texas Southwestern Medical Center $799,870 on September 1, 2026, under the Aging Research program (CFDA 93.866) to conduct a randomized controlled trial testing a multi-dimensional tailored telehealth intervention for heart failure with preserved ejection fraction in older adults. The intervention integrates physical rehabilitation targeting strength, balance, mobility, and endurance with health coaching addressing emotional regulation...
- The National Institute on Aging awarded Texas A&M University $640,059 on September 1, 2026, under the Aging Research program (CFDA 93.866) to investigate cerebellar changes in aging and cognitive decline through longitudinal neuroimaging and functional analysis. The project examines how cerebellar structure, white matter circuits, and task-based functional activation change over time in older adults, with particular focus on individuals experiencing subjective cognitive decline—self-reported...
- The National Institute on Aging awarded The University of Texas Health Science Center at San Antonio $2,147,145 on September 15, 2026, under the Aging Research program (CFDA 93.866) to conduct the Rural Microvascular Contributions to Neurocognitive Decline (RURAL-MIND) study. The study deploys portable MRI neuroimaging, AI-driven image analytics, repeated plasma biomarker profiling, and longitudinal cognitive assessments across 4,000 rural residents in high- and lower-risk counties to...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will provide $302,960 to Harvard T.H. Chan School of Public Health to conduct research on identifying individuals who would benefit most from intensive blood pressure control for preventing cognitive decline and dementia, as well as those at risk of serious adverse events. The research will utilize advanced statistical methods and pooled data from multiple large-scale randomized trials to detect...
- The National Institute on Aging awarded the University of Texas Health Science Center at Houston $417,800 on September 15, 2025, for Project Grant R21AG091823 under the Aging Research program (CFDA 93.866). The award funds investigation of senescence induced by iron overload in brain vasculature, with particular focus on sex-dependent differences in vulnerability to iron-induced endothelial damage. The research employs an iron overload model in aged mice, examining the role of the ROBO4...
- The National Institute on Aging awarded the University of Texas Health Science Center at Houston $429,000 on July 1, 2026, under the Aging Research program (CFDA 93.866) to investigate endothelial senescence intervention in limb muscle ischemia using exercise mimetics. The research will measure the effect of exercise mimesis on preventing or reversing muscle decline associated with peripheral arterial disease in aging populations. The project employs unique transgenic mouse lines, including...
- The National Institute on Aging awarded the University of Utah $10.793 million under the Aging Research program (CFDA 93.866) on September 30, 2025, for a project examining the effects of intensive blood pressure control on mild cognitive impairment, dementia, and plasma biomarker trajectories stratified by Alzheimer's disease pathology in the racially and ethnically diverse SPRINT trial population. The award runs through June 30, 2030, with place of performance in Salt Lake City, Utah. The...
- The National Institute on Aging awarded the University of Virginia $2.877 million on July 1, 2026, under the Aging Research program (CFDA 93.866) to investigate microglia's role in neurovascular coupling and hypertensive cerebral small vessel disease. The project will test the hypothesis that microglial dysregulation of cerebral blood flow leads to hypertensive vascular dementia and endothelial rarefaction as common pathological events with Alzheimer's disease. Aim 1 will employ laser speckle...
- The National Institute on Aging, part of the Department of Health and Human Services, awarded $437,250 to the University of Texas at Dallas on September 1, 2026, under the Aging Research program (CFDA 93.866) to investigate affective forecasting as a strategy for reducing temporal discounting across adulthood. The research addresses a critical gap in interventions for temporal discounting—the tendency to devalue delayed rewards in favor of immediate ones—which has serious implications for health...
The National Institute on Aging awarded The University of Texas Southwestern Medical Center $127,493 on August 1, 2026, under the Aging Research program (CFDA 93.866) to investigate associations between midlife hypertension and brain structure and function changes, and to assess the impact of high-intensity interval training on brain outcomes in middle-aged adults with elevated blood pressure. The project combines retrospective longitudinal analysis with a proof-of-concept randomized controlled trial. Aim 1 leverages the Human Connectome Project in Aging dataset (N=611, ages 36–100 years) to determine associations between blood pressure and two-year longitudinal changes in brain white matter microstructure. Aims 2 and 3 conduct a one-year randomized controlled trial in 72 physically inactive middle-aged adults (ages 40–64 years) with elevated blood pressure or stage 1 hypertension, randomized 1:1 into high-intensity interval training or stretching control interventions to assess impacts on brain structure and function. The award carries the designation K99AG095301 (a research career development award structure pairing mentored K99 funding with independent R00 funding). Performance occurs in Dallas, Texas. The period of performance runs from August 1, 2026, through May 31, 2028. The assistance type is a Project Grant, classified under NIH's standard grant review and award processes for biomedical and behavioral research in aging.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $127.5k | 7/28/26 |