Project Grant K99AG095282
- The National Institute on Aging, part of the Department of Health and Human Services, awarded The Leland Stanford Junior University $1,468,868 on January 15, 2026, under the Aging Research program (CFDA 93.866, Program Grant R01AG097491) to investigate how the brain regulates organismal aging as a neural pacemaker controlling the tempo of aging across multiple organ systems. The research combines high-throughput longitudinal studies in killifish—a vertebrate model with a naturally compressed...
- The National Institute on Aging awarded The Leland Stanford Junior University $630,031 on September 1, 2026, under the Aging Research program (CFDA 93.866) to develop an artificial intelligence-driven metabolic clock for distinguishing healthy aging from Alzheimer's disease and Alzheimer's disease-related dementias. The project uses large-scale untargeted metabolomics to identify metabolic deviations associated with cognitive decline in aging and dementia. The research tests the hypothesis...
- The National Institute on Aging awarded The Leland Stanford Junior University $646,340 on June 15, 2026, under the Aging Research program (CFDA 93.866) to construct and analyze a novel individual-level database linking health trajectories of older adults to the physical, mental, and economic well-being of their family members across multiple generations, covering 1999 to 2024. The recipient will leverage U.S. Census Bureau infrastructure for linking administrative data to examine...
- The National Institute on Aging awarded The Leland Stanford Junior University $423,500 for a Project Grant on August 1, 2026, under the Aging Research program (CFDA 93.866). The recipient will conduct the first rigorous study of neighborhood-level spillover effects of income transfers on health outcomes. The research investigates whether income gains accruing to low-income neighborhood residents generate health improvements among nonrecipients through peer diffusion of healthy behaviors and...
- The National Institute on Aging awarded $648,930 to the Regents of the University of California, doing business as University of California, Berkeley, on August 15, 2026, under the Aging Research program (CFDA 93.866) to develop human stem cell-based microphysiological systems for aging research. The recipient will create a novel human aging-on-a-chip platform integrating fat and liver tissues derived from human induced pluripotent stem cells (hiPSCs) and microfluidics using serum from young...
- The National Institute on Aging awarded The Leland Stanford Junior University $667,539 on September 1, 2026, under the Aging Research program (CFDA 93.866) to support research on mechanisms of brain repair during aging, with the objective of preventing Alzheimer's disease and Alzheimer's disease-related dementia. The research characterizes neural stem cells (NSCs) during injury and aging to identify interventions that boost repair in aging brains. NSCs reside in specific brain regions...
- The National Institute on Aging, part of the Department of Health and Human Services, awarded $533,500 to the Buck Institute for Research on Aging on July 15, 2026, under the Aging Research program (CFDA 93.866). The award funds examination of the role of autonomic innervation in muscle stem cell aging. The research investigates the functional link between autonomic nervous system neurons and muscle stem cells using Drosophila melanogaster as a model organism. The project will refine...
- The National Institute on Aging, part of the Department of Health and Human Services, awarded $298,419 to the Regents of the University of Michigan on February 1, 2026, under the Aging Research program (CFDA 93.866, Assistance Listing Project Grant R01AG097771). The recipient will develop advanced statistical and computational methods for analyzing immune cell data to enhance understanding of the immune system's role in aging and age-related diseases. The project addresses analytical...
- The National Institute on Aging, part of the Department of Health and Human Services, awarded The Leland Stanford Junior University $682,281 on September 1, 2026, under the Aging Research program (CFDA 93.866) to develop a human induced pluripotent stem cell-based three-dimensional brain tissue microsphere model that recapitulates granulin deficiency phenotypes and associated pathology in neurodegenerative diseases including frontotemporal dementia and neuronal ceroid lipofuscinosis. The model...
- The National Institute on Aging awarded The Leland Stanford Junior University $658,147 for Project Grant R01AG096626 on September 1, 2026, under the Aging Research program (CFDA 93.866). The award funds research into mechanisms of skeletal muscle maintenance relevant to Alzheimer's disease and Alzheimer's disease-related dementia. The research examines how mitochondrial dysfunction, particularly reverse electron transport along mitochondrial complex I, contributes to NAD+ depletion during aging....
The National Institute on Aging awarded The Leland Stanford Junior University $127,926 on September 1, 2026, under the Aging Research program (CFDA 93.866) to develop computational methods for analyzing three-dimensional spatial-omics data and apply them to study immune architecture changes in gut-associated lymphoid tissues during aging. The recipient will create machine learning tools and computational workflows to process three-dimensional multiplexed imaging data capturing epigenetic, transcriptomic, proteomic, and structural changes in the duodenum and ileum across the human lifespan. The project addresses a methodological gap: existing computational approaches cannot adequately analyze sparse three-dimensional structures or reveal cellular interactions in multiplexed imaging datasets from intestinal tissue. The investigator has piloted the first human three-dimensional multiplexed imaging atlas of the intestine from eight donors spanning ages 23 to 62, covering duodenum through ileum; the award funds refinement of these methods and their application to characterize how aging reshapes immune compartments across intestinal regions. Understanding spatially localized immune dysfunction is intended to identify therapeutic targets for age-associated gastrointestinal disorders including diverticulitis and irritable bowel syndrome. Performance occurs in Palo Alto, California. The period of performance runs September 1, 2026, through August 31, 2028. This is a project grant, the standard assistance type for individual investigator-initiated research within the NIA portfolio.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $127.9k | 9/1/26 |