Project Grant K99AG095151
- The National Institute on Aging awarded the University of Florida $422,125 on June 1, 2026, under the Aging Research program (CFDA 93.866) to investigate how pathological tau protein affects RNA translation and neuronal function in tauopathies, including progressive supranuclear palsy and Alzheimer's disease. The research will identify RNA transcripts that bind to tau in primary tauopathies, characterize newly translated proteins in the presence of pathological tau, and examine tau-RNA...
- The National Institute on Aging awarded the University of Florida $5.551 million on July 1, 2026, under the Aging Research program (CFDA 93.866) to identify neural signatures that distinguish early Alzheimer's disease from normal aging. The recipient will record electrical activity from ten brain regions across the lifespan in human tauopathy mouse models (HTAU mice) and wild-type controls (C57BL/6J), computing new electrical oscillatory features called electome factors to distinguish between...
- The National Institute on Aging, part of the Department of Health and Human Services, awarded $522,463 to Mayo Clinic Jacksonville on September 1, 2026, under the Aging Research program (CFDA 93.866) to investigate UFM1 as a modifier of tau pathology in Alzheimer's disease and related tauopathies. The research will determine whether changes in the ufmylation cascade represent a universal feature across the tauopathy spectrum, identify the substrates to which UFM1 is conjugated in brain under...
- The National Institute on Aging awarded $191,832 to North Florida Foundation For Research And Education, Inc. on August 15, 2026, under the Aging Research program (CFDA 93.866) to support a K23 career development grant focused on brain aging and Alzheimer's disease risk. The award funds research investigating the relationship between cognition and the autonomic regulatory system in older adults at varying risk for Alzheimer's disease and related dementias. The principal investigator will...
- The National Institute on Aging awarded The Regents of the University of California, San Francisco $681,908 on February 15, 2026, under the Aging Research program (CFDA 93.866) to investigate protective mechanisms of UFM1-dependent IRE1 signaling in tauopathies, with work performance in San Francisco, California through November 30, 2030. The project addresses tau protein aggregation in Alzheimer's disease and related tauopathies by elucidating molecular mechanisms linking the ufmylation pathway...
- The National Institute on Aging awarded The Regents of the University of California, San Francisco $663,237 on September 1, 2026, under the Aging Research program (CFDA 93.866) to support multiscale structural approaches defining tau filaments and cellular dysfunction associated with Alzheimer's disease and related dementias (ADRDs). The research integrates histological and structural imaging methods with cryo-electron microscopy to characterize tau fibril structures, aggregate morphologies, and...
- The National Institute on Aging awarded Rutgers, The State University $225,256 on May 1, 2026, under the Aging Research program (CFDA 93.866) to investigate the role of big tau protein in preventing tau pathology in Alzheimer's disease. The research examines why selective brain regions such as the cortex and hippocampus develop tau pathology in Alzheimer's disease while the cerebellum and brainstem largely remain intact. The investigator has identified big tau, a tau isoform with a...
- The National Institute on Aging awarded the University of Florida Division of Sponsored Research $507,214 under Project Grant R21AG094050 on February 15, 2026, to assess the role of long-noncoding RNA SLAMR in Alzheimer's disease pathogenesis. The award funds investigation of SLAMR regulation of expression and function in AD development, including systematic functional experiments in APP knock-in (APP NL-G-F) and tau (PS19) mouse models of AD to determine whether SLAMR-mediated translation and...
- The National Institute on Aging awarded Ohio University $567,256 on February 1, 2026, under the Aging Research program (CFDA 93.866) to investigate the mechanisms of activity-dependent tau release in Alzheimer's disease pathogenesis. The research elucidates how neuronal hyperexcitability drives tau release from neurons and synapses, using a Drosophila model and human neural cell lines. Aim 1 investigates activity-dependent tau release from neurons and synapses, focusing on synaptic vesicle...
- The National Institute on Aging, part of the Department of Health and Human Services, awarded the University of California, Los Angeles $146,750 under the Aging Research program (CFDA 93.866) on July 1, 2026, to identify molecular-neuropathological signatures in Alzheimer's disease, frontotemporal lobar degeneration, and long COVID. The recipient will employ single-cell spatial multi-omics on postmortem brain tissues to characterize molecular and cellular alterations linked to selective...
The National Institute on Aging awarded the University of Florida $119,502 on August 5, 2026, under the Aging Research program (CFDA 93.866) to support a K99 Project Grant (K99AG095151) investigating tau pathology in Alzheimer's disease through multi-omics approaches. The award funds research using spatial transcriptomics and metabolomics technologies to determine how pathological tau mediates disease spread from brainstem serotonin-producing raphe nuclei to healthy brain regions. The research employs the median raphe nucleus-to-hippocampus circuit as a model system to identify specific factors through which tau pathology disrupts neuronal excitability and metabolic balance, with preliminary data suggesting tau may dysregulate ion-channel gene expression. The work incorporates advanced training in spatial transcriptomics and metabolomics, utilizing combinatorial genetics tools and a preclinical model developed to interrogate the research hypothesis linking trans-synaptic tau pathology to gene-expression changes that reinforce neuronal pathology. Performance occurs in Gainesville, Florida, with a period of performance from August 5, 2026, through July 31, 2028. The University of Florida Division of Sponsored Research administers the award as the recipient institution.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $119.5k | 8/4/26 |