Project Grant K99AG090620

Award Date 12/1/24
Completion Date 11/30/26
Dollars Obligated $133K
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
Rochester, MN 55905, USA
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This $133,353.00 federal Project Grant award was provided by the National Institute on Aging (NIA) under the Aging Research (CFDA 93.866) program. The grant supports research conducted by Mayo Clinic to investigate the molecular mechanisms of T cell-mediated surveillance and elimination of senescent cells under both physiological and aging conditions.

Specifically, the research aims to: 1) define how various types of senescent cells deploy their secretome to sensitize human T cells toward activation, survival, and retention; 2) assess co-stimulatory and co-inhibitory interactions between senescent cells and T cells; and 3) elucidate spatially resolved T cell surveillance of renal senescent cells and conduct mechanistic studies in isolated primary renal cells. This work is expected to provide critical insights into senescent cell immune evasion and lay the foundation for the development of immunotherapies targeting pathological senescent cell accumulation during the aging process.

The grant period runs from December 1, 2024 to November 30, 2026, with the research being carried out at Mayo Clinic.

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