The federal Project Grant award R01GM157610 for $179,703.00 was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The grant supports a research project titled "DISEASE GENE DISCOVERY BY MARKOVIAN GENE NETWORK" to be conducted by Rutgers, The State University in New Brunswick, NJ. The project aims to advance understanding in areas such as molecular biology, genetics, biochemistry, and...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $1,570,000.00 to Rutgers, The State University to conduct research on RNA-mediated chromatin regulation and transgenerational epigenetic inheritance in C. elegans. The key objectives of this 5-year project are to: 1) investigate the function and enzymology of the novel histone modification H3K23me3, which is involved...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) will provide $393,750.00 to the University of California, Los Angeles (UCLA) to explore the fundamental cellular mechanisms driving cellular senescence in macrophages. The research aims to gain a deeper understanding of the cellular and molecular mechanisms underlying senescent macrophage biology, focusing on the role of cell cycle arrest genes,...
This $360,247 federal Project Grant award was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859) to Rutgers, The State University of New Jersey. The funding supports research focused on exploring the diverse mechanisms of Type III CRISPR-Cas signaling in microbes, including bacteria and archaea. The research aims to investigate the function and regulation of CRISPR signaling effectors, particularly...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) provides $392,500.00 over 5 years (1/1/2025 - 12/31/2029) to Rutgers, The State University of New Jersey to mechanistically characterize the enzymology of human ribosome biogenesis. The research aims to fill a key knowledge gap in understanding the molecular mechanisms underlying the ATP-driven, force-producing enzymes that...
This $1,737,000 Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports the development of innovative single-cell genomics technologies for joint analysis of regulatory dynamics and transcriptional states. Key objectives include: Developing multiomics tools to measure rates of epigenomic changes (DNA methylation, demethylation, oxidative damage, DNA repair) and relate these to...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training Program (CFDA 93.859), provides $380,587 to The Johns Hopkins University to support research on defining the biophysical basis for cell types, cell states, and cellular heterogeneity at single-cell resolution. The goal is to comprehensively understand how the flow of biological information from molecular programs to cellular behaviors and responses defines...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) totaling $431,750 will fund research to identify molecular features associated with age-related vascular alterations. The research aims to isolate and characterize peptide ligands that target vascular endothelial cells (VECs) in young versus aged mice, as well as senescent versus non-senescent murine VECs. The primary goal is to enhance the understanding of molecular mechanisms underlying age-related...
This $1,177,500 five-year Project Grant award from the National Institute of General Medical Sciences (NIGMS) under CFDA Program 93.859 (Biomedical Research and Research Training) will support research by Rutgers, The State University of New Jersey to advance understanding of one-carbon metabolism and its role in regulating epigenetic processes across different tissue types and cell proliferation states. The key objectives are to: 1) quantify rates of S-adenosyl-methionine (SAM) production and...
This National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) project grant, valued at $1,218,750.00 and awarded on August 1, 2024, supports research to characterize the regulatory networks and mechanisms of retrotransposable elements (REs) in mammalian development. The project aims to leverage this understanding to explore the therapeutic potential of "synthetic RE-reactivation" to re-engage beneficial properties in...