Project Grant R21AG088872

Award Date 9/1/24
Completion Date 8/31/26
Dollars Obligated $209K
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
Charlestown, MA 02129, USA
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This Federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $224,140 to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), to conduct research on understanding the relationship between cortical hyperexcitability and the progression of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) pathology and behavioral deficits in mice. The key objectives of this 2-year research project are to: 1)...
This National Institute on Aging (NIA) Project Grant, CFDA 93.866 Aging Research, was awarded to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), to profile and forecast individual progression in Alzheimer's disease and related dementias (ADRD) using machine learning. The $129,330 grant will fund a project to deploy a multi-modal data framework leveraging decades-long in vivo and digital biomarkers to classify ADRD subtypes and predict...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to The General Hospital Corporation (doing business as Massachusetts General Hospital) is for a 2-year research project titled "INFERENCE BY INTERFERENCE: TASK-DEPENDENT PUPIL RESPONSES AS AN EARLY DETECTION METHOD FOR ALZHEIMER'S DISEASE RELATED BRAINSTEM FUNCTIONAL CHANGE". The $426,353 project aims to identify early biomarkers of Alzheimer's disease by studying pupil responses during...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to Brandeis University will conduct research to understand the neurobiological mechanisms underlying daily life activity participation in older adults and its relationship to Alzheimer's disease pathology. The $148,568 award, running from November 2024 to January 2026, will employ a multilevel, multimodal approach using behavioral, psychophysiological, neuroimaging, and naturalistic methods. Key...
This federal Project Grant award, totaling $198,355.00, was provided by the National Institute on Aging under the Aging Research grant program (CFDA 93.866) to The Johns Hopkins University. The primary objective is to conduct a Positron Emission Tomography (PET) study to measure changes in neural circuitry associated with affective symptoms (depression, anxiety, irritability, agitation) and cognitive deficits in patients with behavioral variant frontotemporal dementia (bvFTD). The research...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $2,001,864 to Harvard University to investigate the subcellular mechanisms underlying the selective vulnerability of specific neuron subtypes in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The researchers will quantitatively study the localization of RNA, proteins, and translational regulation in the synapses and soma of vulnerable corticospinal neurons (CSN) and...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will fund a pilot study to evaluate the feasibility of using non-invasive neuroimaging techniques to monitor the metabolic and vascular functions of the brain and heart in a mouse model of Alzheimer's disease (AD). The $332,096 award, with a performance period from July 2024 to June 2026, will be made to The General Hospital Corporation (doing business as Massachusetts General Hospital). The research...
This Project Grant award, valued at $134,730.00, was issued by the National Institute on Aging (NIA), under the Aging Research federal grant program (CFDA 93.866), to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH). The goal of this project is to develop electroencephalogram (EEG) biomarkers to predict the future risk of dementia and monitor cognitive decline in older adults. The research will leverage existing datasets from the National Sleep Research...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $4,085,619 to Vanderbilt University Medical Center (VUMC) to conduct research on antisocial behaviors in frontotemporal dementia (BVFTD). The key objectives are to: 1) define distinct behavioral phenotypes for aggressive vs. rule-breaking behaviors in BVFTD, 2) investigate the neural correlates of these distinct antisocial behaviors, and 3) examine how socioemotional impairments relate to the...
This National Institute on Aging (NIA) Project Grant (CFDA 93.866 - Aging Research) in the amount of $2,398,069 will fund a pathologically-grounded study of biofluid biomarkers in autopsy- and genetically-confirmed frontotemporal lobar degeneration (FTLD) subtypes at the University of Pennsylvania. The goal is to develop multi-analyte algorithms for screening and prognosis of FTLD, a family of neurodegenerative proteinopathies lacking effective treatments. The study will leverage the...

This $208,750 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will fund a research project titled "Characterizing Autonomic Impairments in Frontotemporal Dementia" at The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH). The primary objectives are to:

  1. Assess the test-retest reliability of "gold-standard" measurements of autonomic function in 30 patients with behavioral variant frontotemporal dementia (bvFTD) and 30 matched controls in a controlled laboratory setting. This will establish that bvFTD patients have detectable and stable autonomic impairments compared to controls.

  2. Evaluate the test-retest reliability of ambulatory wearable technologies to measure autonomic function in the same laboratory environment, and correlate the results to gold-standard metrics to validate the ambulatory measures.

  3. Assess the feasibility of using ambulatory autonomic assessments in both subject groups at home.

  4. Correlate gold-standard and ambulatory autonomic measurements to validated ratings of socioemotional function.

This research is intended to advance the characterization of autonomic dysfunction in bvFTD and its relationship to socioemotional impairments, a core feature of the disease. The project will run from September 1, 2024 to August 31, 2026.

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