Project Grant R21AA031101

Award Date 9/12/23
Completion Date 8/31/25
Dollars Obligated $405K
Federal Grant Program
93.273
Assistance Type
Project Grant
Place of Performance
New York, USA
Similar Awards
This federal Project Grant award, totaling $517,248.00, was issued by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) grant program. The award supports research to explore the mechanisms by which acute and chronic alcohol exposure regulate a norepinephrine-astrocyte-dopamine arousal pathway in the ventral periaqueductal gray (VPAG) region of the brain, and how this pathway contributes to alcohol-related changes in sleep behavior....
This Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA), under the Alcohol Research Programs (CFDA 93.273) federal grant program, will support the development and testing of a novel in vivo model called CHIMERA-BONCAT. This model will enable comprehensive, unbiased, and cell-type-specific characterization of the human microglial response to alcohol exposure. The $214,385 award, with a period of performance from August 2024 to July 2026, will fund research...
This federal Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA), under the Alcohol Research Programs (CFDA 93.273) program, provides $499,442 in funding to The Regents of the University of California, San Francisco (UCSF) from August 20, 2024 through July 31, 2027. The award supports research to investigate the role of brain-derived neurotrophic factor (BDNF) signaling in the ventral hippocampus and its contribution to the acute anxiolytic and social...
This federal Project Grant award, totaling $165,279.00, was provided by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) federal grant program. The award aims to understand the neural markers of incentive salience for alcohol cues and the role of context in brain-behavior relationships for alcohol use disorder (AUD). The research will leverage a combined laboratory-ambulatory study design to characterize the brain-behavior...
This federal Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA), under the Alcohol Research Programs (CFDA 93.273) grant program, will support research to investigate the role of sex chromosomes in alcohol drinking behaviors. The total award amount is $321,102 and the project will run from August 1, 2024 to July 31, 2029. The key objectives of the research are to: 1) demonstrate that alcohol consumption is reduced in mice with two X chromosomes compared to...
This federal Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA), under the Alcohol Research Programs (CFDA 93.273) federal grant program, will support the development of novel 3D human brain circuits to investigate the role of microglia in alcohol use disorder (AUD) and Alzheimer's disease (AD) pathology. The $223,531 award to the University of North Carolina at Chapel Hill will fund research to elucidate how alcohol-induced changes in microglial metabolism...
The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded a $537,587 Project Grant under the Alcohol Research Programs (CFDA 93.273) to The University of Texas Southwestern Medical Center to conduct research on the metabolic consequences of liver inflammation on alcohol consumption and alcohol-associated liver disease (ALD). The key objectives are to identify the mechanisms by which the transcription factor IRF3 suppresses the expression and secretion of the metabolic regulator...
This Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA), under the Alcohol Research Programs (CFDA 93.273) federal grant program, supports research into the neuroepigenetic mechanisms underlying the transgenerational behavioral effects of alcohol exposure. The primary objectives are to: 1) Identify the neuronal epigenetic changes, particularly histone acetylation patterns, that accompany ethanol exposure, and 2) Determine the role of neuronal histone...
The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded a $194,551 Project Grant under the Alcohol Research Programs (CFDA 93.273) to The Medical University of South Carolina. The funding supports research to investigate the effects of adolescent intermittent ethanol exposure on the regulation of a neural pathway involving the prelimbic cortex and ventrolateral periaqueductal gray, and its impact on pain processing and sensitivity. The research aims to elucidate how changes in the...
This $156,204 Project Grant award, funded by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273), supports research to investigate the role of BNST PKCdelta neurons in compulsive ethanol intake behaviors. The research aims to: 1) Evaluate adaptations in BNST PKCdelta neuron calcium transients across an abstinence period during operant behavior; 2) Dissect population dynamics in BNST PKCdelta calcium transients in response to ethanol...

This Project Grant award in the amount of $404,508.00 was provided by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) federal grant program.

The award aims to examine interleukin-1β (IL-1β) synaptic regulation and its role in cognitive impairment during early withdrawal and protracted abstinence from chronic alcohol exposure in male and female mice. The overarching goal is to determine the neuroimmune mechanisms by which chronic ethanol produces long-lasting changes in the medial prefrontal cortex function. The proposed studies seek to fill critical gaps in knowledge regarding IL-1β/neuroimmune regulation of basal prefrontal function, provide information on the sex-dependent consequences of chronic ethanol on the IL-1/neuroimmune system, and potentially identify a novel pharmaceutical target for treating the cognitive symptoms of alcohol use disorder. The award has an ultimate completion date of August 31, 2025.

Generated 7/16/24, 8:42 AM