Project Grant K76AG095138
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $639,740.00 to investigate the role of the CD38 enzyme in the development of chronic lung conditions following viral infections like COVID-19. The research aims to explore how targeting CD38 on CD8 tissue resident memory (TRM) cells could mitigate age-associated lung fibrosis after viral pneumonia. The award, effective December 15, 2024 through November 30, 2029, will support the lead researcher...
- This federal Project Grant award from the National Institute on Aging (NIA), part of the U.S. Department of Health and Human Services, provides $667,664 to the University of Pittsburgh to study the impacts of air pollution and cigarette smoke on lung aging. The project, running from August 2025 to July 2027, will utilize human organoid and precision cut lung slice models to define how particulate matter (PM2.5) and cigarette smoke exposure influence mitochondrial dysfunction and cellular...
- This Project Grant award of $800,679.00 from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) will support the University of Virginia's research to interrogate the pathogenesis of chronic obstructive pulmonary disease (COPD) using metabolomics and genomics data. The objective is to expand the PredixCan method to incorporate metabolomics data, creating a new tool called MetaBoxCan, in order to extract more comprehensive mechanistic information from...
- This Project Grant award, provided by the National Institute on Aging (NIA) under the Aging Research Federal Grant Program (CFDA 93.866), aims to elucidate the role of reverse electron transport (RET) in lung aging and idiopathic pulmonary fibrosis (IPF). The $460,283 award to the University of California, San Francisco (UCSF) supports a 2-year investigation focused on two key objectives: 1) conducting a detailed gene expression analysis to understand RET's influence on pro-fibrotic gene...
- This $789,664 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will support a research project titled "Dissecting the Cellular and Spatial Tissue Clock of the Human Lung and Peripheral Blood" at the Icahn School of Medicine at Mount Sinai. The project aims to leverage single-cell RNA sequencing and spatial transcriptomics to characterize the effect of age on the cellular microenvironment of the human lung and peripheral blood. The research will...
- This federal Project Grant award, valued at $158,652 and provided by the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research), supports research into the impact of alveolar macrophage senescence in aged donor lungs on post-lung transplant outcomes. The award, with a start date of September 1, 2025 and an ultimate completion date of August 31, 2030, will be carried out by Duke University's Office of Research Administration Division. The research aims to...
- This $116,625 federal Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) will characterize clinically relevant phenotypes related to osteoporosis and sarcopenia in chronic obstructive pulmonary disease (COPD). The project will develop automated methods to derive static metrics of spine, vertebrae, and pectoral muscles, as well as dynamic metrics of lung diaphragmatic surface deformation, from chest CT scans. It will then use...
- This Project Grant award of $762,867.00 from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) aims to investigate the role of the cofilin-1 protein in regulating mitochondrial function and quality control in airway epithelial cells. The research, conducted by The Johns Hopkins University, seeks to understand how the loss of cofilin-1 impacts mitochondrial dynamics and mitophagy, and how these processes contribute to airway epithelial dysfunction in...
- This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) provides $151,578.00 to Cleveland Clinic Lerner College of Medicine of Case Western Reserve University to investigate the role of hypoxia-inducible factor 1-alpha (HIF1A) in skeletal muscle protein homeostasis and function in a mouse model of chronic obstructive pulmonary disease (COPD)-associated sarcopenia. The research aims to determine how...
- This federal Project Grant award of $113,683 from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) supports research to characterize the determinants of cellular senescence and epigenetic dysregulation caused by tobacco smoke exposure in the lung. The research aims to: Determine the time- and age-dependent effects of cigarette smoke exposure on lung cellular senescence and associated epigenetic regulation in mouse models. Study the determinants of...
This Project Grant award, titled "Investigating Senolytic Properties in Pulmonary Rehabilitation and Metformin in COPD Exacerbations (INSPIRE-COPD-E)", is funded by the National Institute on Aging (CFDA 93.866 - Aging Research) for $243,000. The award, which runs from September 1, 2025 to June 30, 2030, aims to evaluate two senotherapeutic approaches - pulmonary rehabilitation (PR) and metformin - to decrease the likelihood of chronic obstructive pulmonary disease (COPD) exacerbations in older adults. The project will investigate how these interventions can reduce senescent T-cells and the associated inflammatory secretory phenotype, thereby improving immune response and protection against respiratory infections, a common cause of COPD exacerbations. The award recipient is Duke University, which will leverage its extensive research capabilities in medical research, clinical trials, and biomedical engineering to conduct this comprehensive investigation.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $243.0k | 8/27/25 |