This is a Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242). The $194,899 award will fund a 5-year research project led by Dr. Rapp at the Icahn School of Medicine at Mount Sinai to investigate the neurocognitive mechanisms underlying compulsivity, with a focus on obsessive-compulsive disorder (OCD). The research will use computational modeling and EEG analysis to examine how the integration of goal-directed...
This Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), will support research into the neural mechanisms and neuromodulation of affective states. The $381,915 award to the Icahn School of Medicine at Mount Sinai will fund an investigation to determine the neural and physiological biomarkers of mood-like states in non-human primates. The research will combine computational modeling, multi-region...
This federal Project Grant award, funded by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), is supporting research to investigate the role of frontal parvalbumin interneuron maturation in the development of attentional abilities. The $127,305 award, granted on May 2, 2025 with a completion date of April 30, 2027, will enable the Icahn School of Medicine at Mount Sinai to conduct experiments integrating techniques for manipulating...
This Project Grant award of $633,438 from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), supports research by New York University to develop a data-driven framework for real-time neural control. The key objectives are: Investigating the spatial and temporal summation rules governing multi-electrode microstimulation in primate prefrontal cortex to uncover principles of nonlinear summation and interaction effects. Introducing a...
This federal Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $829,966 to the Icahn School of Medicine at Mount Sinai to conduct research on the neural mechanisms of social information processing. The overarching objective is to determine how the brain integrates diverse social information, such as familiarity and hierarchy, to form coherent social representations. The research will leverage...
This federal Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $100,748.00 to the Icahn School of Medicine at Mount Sinai to investigate the neurocomputational mechanisms underlying the influence of social interaction on mood. The key objectives of this 2.5-year research project are to: 1) use computational modeling to examine how norm prediction errors influence short-term and long-term changes in...
This Project Grant award of $338,600 from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) will support research to investigate the neural circuits underlying egocentric and allocentric cognitive maps in humans. The project, led by the Trustees of Columbia University, will utilize computational modeling and single-neuron recordings in epilepsy patients to demonstrate the neural basis of these spatial cognitive maps and how they are...
This federal Project Grant award in the amount of $1,920,113.00 was provided by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242). The grant supports research aimed at narrowing the mechanistic gap for understanding the function of the anterior lateral prefrontal cortex (ALPFC), a brain region implicated in various mental health disorders. The key objectives of the research project are: 1) Evaluating the domain-generality of ALPFC's...
This Project Grant award, valued at $638,872, was provided by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242). The objective is to identify metabolic and functional imaging changes in the reward network that occur as a result of deep brain stimulation (DBS) of the medial forebrain bundle (MFB) in patients with treatment-resistant depression. Key goals include characterizing the temporality of reward network changes induced by MFB...
The federal Project Grant award R01MH139352, totaling $429,323.00, was provided by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants (CFDA 93.242) program. The grant supports research to investigate cognitive flexibility and the neural mechanisms underlying cognitive thalamocortical dynamics, with the goal of advancing understanding and treatment of mental illnesses characterized by cognitive inflexibility, such as schizophrenia. The primary awardee is New...