This federal Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $2,405,632 to the Icahn School of Medicine at Mount Sinai to conduct research on the "Neurocomputational Mechanisms and Connectivity Dynamics Underlying Obsessive-Compulsive Disorder and Phenotypical Differentiations." The 5-year project, starting June 10, 2024, aims to use neuroimaging, computational modeling, and...
The National Institute of Mental Health (NIMH) awarded a $194,460 Project Grant (CFDA 93.242 - Mental Health Research Grants) to the Icahn School of Medicine at Mount Sinai (ISMMS) to conduct research on the circuit-level computational deficits underlying compulsivity in psychiatric disorders. The project aims to directly characterize and correct these deficits using deep brain stimulation (DBS) technology in human subjects with severe obsessive-compulsive disorder (OCD). The research will...
The National Institute of Mental Health (NIMH) awarded a $239,250 Project Grant under the Mental Health Research Grants program (CFDA 93.242) to Stony Brook University's Research Foundation. The award, titled "Exploratory Study of the Cholinergic System in Obsessive Compulsive Disorder (OCD)," aims to provide initial proof-of-concept for a novel target in OCD based on observations in mouse models. The research team, led by Co-PI Joshua Plotkin, will scan 10 OCD patients and 10...
The University of Southern California (USC) has been awarded a $1,330,840 Project Grant from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242). The 5-year grant, titled "MEGA-OCD: A Global Data-Driven Initiative to Discover Biosignatures of OCD," aims to establish robust, reproducible biosignatures of obsessive-compulsive disorder (OCD) through a large-scale, international neuroimaging study. The project will leverage data...
This $106,668 Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) supports research at the University of Pittsburgh on the role of the medial orbitofrontal cortex (MOFC) in negative reinforcement learning. The project aims to investigate the cellular and circuit-level mechanisms by which the MOFC drives avoidance behaviors in obsessive-compulsive disorder (OCD). Specifically, the research will use microendoscopy...
The National Institute of Mental Health (NIMH) awarded a 5-year, $721,862 Project Grant (CFDA 93.242 - Mental Health Research Grants) to The University of Kentucky Research Foundation to characterize and modulate functional connectivity and fear extinction abnormalities in obsessive-compulsive disorder (OCD). The grant will examine neural mechanisms underlying safety learning and memory deficits in OCD, as well as test whether frontopolar transcranial direct current stimulation can normalize...
The National Institute of Mental Health (NIMH) awarded a Project Grant (CFDA 93.242) totaling $678,430 to the University of California, Berkeley to investigate frontostriatal dynamics during decision-making. The research aims to elucidate the role of the orbitofrontal cortex (OFC) in inhibiting habitual responses in the striatum, which is theorized to underlie compulsive behaviors observed in various neuropsychiatric disorders. The project will utilize a novel behavioral task and advanced...
This Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) provides $859,577 to the Icahn School of Medicine at Mount Sinai (ISMMS) to systematically investigate the phenotypes of obsessive-compulsive disorder (OCD) in African American populations and identify rare genetic variants contributing to OCD susceptibility in this underrepresented group.
The project aims to recruit at least 1,250 African American OCD...
This federal Project Grant award of $199,739, provided by the National Institute on Disability, Independent Living, and Rehabilitation Research (CFDA 93.433), will support research to help adults with obsessive compulsive disorder (OCD) succeed at work through the Individual Placement and Support (IPS) model of supported employment. The award, which runs from September 1, 2024 to August 31, 2027, will be implemented by the Research Foundation for Mental Hygiene, Inc. (RFMH), doing business as...
This is a Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242). The $189,540 grant, awarded on February 1, 2025, aims to determine how model-based decision-making is represented in the neural circuitry of the prelimbic cortex and dorsomedial striatum in mice. The primary activities include monitoring and manipulating neural activity using in vivo electrophysiology and optogenetics to understand the roles of...