Project Grant K23MH133997

Award Date 4/1/25
Completion Date 3/31/30
Dollars Obligated $195K
Federal Grant Program
93.242
Assistance Type
Project Grant
Place of Performance
New York, NY 10029, USA
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This federal Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $2,405,632 to the Icahn School of Medicine at Mount Sinai to conduct research on the "Neurocomputational Mechanisms and Connectivity Dynamics Underlying Obsessive-Compulsive Disorder and Phenotypical Differentiations." The 5-year project, starting June 10, 2024, aims to use neuroimaging, computational modeling, and...
The National Institute of Mental Health (NIMH) awarded a $194,460 Project Grant (CFDA 93.242 - Mental Health Research Grants) to the Icahn School of Medicine at Mount Sinai (ISMMS) to conduct research on the circuit-level computational deficits underlying compulsivity in psychiatric disorders. The project aims to directly characterize and correct these deficits using deep brain stimulation (DBS) technology in human subjects with severe obsessive-compulsive disorder (OCD). The research will...
The National Institute of Mental Health (NIMH) awarded a $239,250 Project Grant under the Mental Health Research Grants program (CFDA 93.242) to Stony Brook University's Research Foundation. The award, titled "Exploratory Study of the Cholinergic System in Obsessive Compulsive Disorder (OCD)," aims to provide initial proof-of-concept for a novel target in OCD based on observations in mouse models. The research team, led by Co-PI Joshua Plotkin, will scan 10 OCD patients and 10...
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This $106,668 Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) supports research at the University of Pittsburgh on the role of the medial orbitofrontal cortex (MOFC) in negative reinforcement learning. The project aims to investigate the cellular and circuit-level mechanisms by which the MOFC drives avoidance behaviors in obsessive-compulsive disorder (OCD). Specifically, the research will use microendoscopy...
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This Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) provides $859,577 to the Icahn School of Medicine at Mount Sinai (ISMMS) to systematically investigate the phenotypes of obsessive-compulsive disorder (OCD) in African American populations and identify rare genetic variants contributing to OCD susceptibility in this underrepresented group. The project aims to recruit at least 1,250 African American OCD...
This federal Project Grant award of $199,739, provided by the National Institute on Disability, Independent Living, and Rehabilitation Research (CFDA 93.433), will support research to help adults with obsessive compulsive disorder (OCD) succeed at work through the Individual Placement and Support (IPS) model of supported employment. The award, which runs from September 1, 2024 to August 31, 2027, will be implemented by the Research Foundation for Mental Hygiene, Inc. (RFMH), doing business as...
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This $194,899 federal Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) supports research to advance the understanding of neurocognitive mechanisms underlying compulsivity, with a focus on obsessive-compulsive disorder (OCD).

The primary objectives of this 5-year award are to: 1) use theory-driven computational modeling and trial-by-trial EEG analysis to investigate how impairments in the integration of goal-directed and habitual behavioral control systems contribute to compulsive symptoms in OCD, and 2) provide the awardee, Dr. Rapp, with advanced training in precision analytic methods and career development toward research independence. The research will involve a study of 50 unmedicated adults with OCD and 50 healthy controls, who will complete reinforcement learning tasks while EEG is recorded before and after a 10-week course of exposure and response prevention therapy. The study aims to reveal the temporally precise neural dynamics underlying compulsive behaviors and link these findings to clinically relevant outcomes, laying the groundwork for future R01 grant proposals.

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