This federal Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) supports a research project titled "Neural Mechanisms and Neuromodulation of Affective States." The $127,305 award aims to investigate the neural circuits and computational mechanisms that translate prediction error signals into fluctuations in affective states, such as mood, in non-human primates. The research will combine neurophysiology, computational modeling, and targeted neuromodulation techniques like transcranial focused ultrasound to elucidate the causal relationship between prediction errors, neural activity in the subgenual cingulate cortex, and changes in affective states. This work is intended to provide foundational insights into the neural basis of mood regulation in healthy individuals as well as potential dysfunctions in clinical disorders like depression. The award, with a period of performance from July 2024 to June 2026, will support a multi-disciplinary training program for the principal investigator to develop expertise in advanced neurophysiology, computational neuroscience, and translational research.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $127.3k | 7/22/24 |