This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under CFDA Program 93.837 Cardiovascular Diseases Research, provides $402,117 to the University of North Carolina at Chapel Hill. The award will support the adaptation and pilot testing of a family-centered intervention, SUCCEED-ICU, designed to improve long-term outcomes for survivors of acute respiratory failure. The project aims to: 1) adapt the existing SUCCEED intervention for use in acute respiratory...
This Project Grant award of $696,470.00 from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) supports research at the University of Denver to investigate the relationship between prenatal maternal sleep and offspring cardiovascular disease risk. The research aims to: 1) examine how prenatal maternal sleep trajectories predict maternal biological pathways like inflammation and stress, 2) assess how prenatal maternal sleep impacts offspring growth,...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under CFDA 93.837 "Cardiovascular Diseases Research" will provide $126,059 from September 1, 2024 to August 31, 2029 to the University of Colorado-Denver. The project aims to use proteomics and metabolomics approaches to study the systems biology of acute and chronic multi-organ failure in children with congenital heart disease (CHD). Specifically, the project will measure changes in the circulating...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $234,000.00 to The Regents of the University of Colorado, doing business as the University of Colorado-Denver, to conduct secondary analysis of noninvasive imaging biomarkers for early prediction of single ventricle heart disease (SVD) failure. The project aims to noninvasively quantify systemic and pulmonary vascular compliance through...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $477,290 to Mayo Clinic to investigate the underlying behavioral mechanisms that impact a home-based pulmonary rehabilitation program for patients with chronic obstructive pulmonary disease (COPD). The research aims to determine the associations between patterns of physical activity, sedentary behavior, sleep, and cognitive...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under CFDA 93.837 - Cardiovascular Diseases Research provides $189,000.00 to the University of Utah to conduct a 5-year research program with the goal of developing the Principal Investigator into an independent, patient-oriented clinical researcher focusing on the pathophysiology of cardiogenic shock (CS) and its overlap with the cardiorenal syndrome. The key objectives of the research are to: 1) evaluate the...
This federal Project Grant award of $725,088 from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) aims to optimize the effectiveness and implementation of COPD self-management treatment. The primary goal is to conduct a factorial optimization trial among 448 individuals with COPD to evaluate the impacts of treatment components including self-management education, physical activity, and inhaler training on respiratory-related hospitalizations and...
This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $1,451,812 to Oregon Health & Science University to conduct a longitudinal study on sleep, pain, and executive function outcomes in pediatric intensive care unit (PICU) survivors. The key objectives are to: 1) identify pain trajectories and biopsychosocial risk factors for chronic pain, 2) elucidate longitudinal sleep disturbances and sleep-pain...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) provides $190,825 to investigate right ventricular (RV) function and exercise training for patients with chronic obstructive pulmonary disease (COPD). The research aims to identify patterns of RV contractile response to aerobic exercise and assess the feasibility of an exercise training intervention targeted to improve RV function. The...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), is providing $1,147,992 to The Regents of the University of California, San Francisco (UCSF) to conduct research aimed at advancing precision medicine for acute respiratory distress syndrome (ARDS) and sepsis. The key focus is on deeply phenotyping human samples to understand the functional immune response and pathogen drivers of...
This Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $180,936 to the University of Colorado-Denver to conduct research aimed at promoting a culture of sedation minimization in intensive care units (ICUs). The overarching goal is to understand how individual ICU staff characteristics and organizational culture influence team dynamics and collaboration around implementing evidence-based sedation minimization strategies, such as the Spontaneous Awakening Trial (SAT). The research will involve surveying ICU staff, qualitative analysis of team interactions, and the development and piloting of a multifaceted implementation program to improve adoption and fidelity of SAT in a single ICU setting. This work is intended to catalyze a fundamental culture change in ICUs to reduce unnecessary deep sedation of patients receiving mechanical ventilation. The project period runs from July 2025 through June 2030.