Project Grant K23HD117006
- This Project Grant award of $425,628.00 from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research federal grant program (CFDA 93.865), aims to elucidate the role of the FMR1 gene in regulating reproductive function. The overarching goal is to investigate the molecular mechanisms by which FMR1 gene mutations, which cause Fragile X syndrome and premature ovarian failure, impact ovarian function...
- This Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), provides $121,920 to investigate the role of the RFT1 protein in regulating growth and developmental signaling. The research aims to elucidate how RFT1, which is associated with a rare congenital disorder of glycosylation, impacts the Hedgehog signaling pathway and downstream mTOR Complex...
- This $163,145 Project Grant awarded on August 7, 2025 by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research Program (CFDA 93.865), aims to address critical questions pertaining to impaired placentation associated with fetal growth restriction (FGR). The principal investigator, a pediatric and fetal surgeon, will use this 5-year award to develop unique cross-disciplinary skills and...
- This Project Grant award of $474,878 from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) will support research to quantify the impact of hyperglycemia on embryonic metabolism and development in C. elegans. The key objective of this 2-year project is to generate single-cell resolution data on how cellular metabolism changes over the course of embryonic development in normal and...
- This Project Grant award of $226,608.00 from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) is funding research to identify the mechanistic link between fetal glucagon and placental nutrient delivery. The goal is to establish how fetal glucagon regulates placental lactogen secretion and uterine blood flow as an adaptive mechanism for matching nutrient supply to...
- This Project Grant award of $765,571 from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), supports research on placental fatty acid metabolism in gestational diabetes mellitus (GDM). The project aims to investigate sexual dimorphism in placental function and its role in adverse pregnancy outcomes associated with GDM, with a focus on understanding the effects of GDM...
- The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) awarded a $746,999 Project Grant under the Child Health and Human Development Extramural Research program (CFDA 93.865) to The Broad Institute, Inc. to characterize the genetic etiology of delayed puberty and rare congenital forms of infertility. The research project aims to: 1) Define the spectrum of genomic variants contributing to idiopathic hypogonadotropic hypogonadism (IHH) and Kallmann syndrome...
- This Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) provides $352,674 to The Research Foundation for the State University of New York (RF-SUNY) at the University at Albany to conduct research on the molecular mechanisms underlying terminal nerve development, GnRH-1 neuronal migration, and olfactory bulb formation in normal and pathological...
- This federal Project Grant award of $108,512 from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), aims to investigate the mechanisms by which the salt-inducible kinase 3 (SIK3) regulates fertility and ovarian granulosa cell function. The research focuses on elucidating SIK3's upstream regulation, downstream targets, and role in metabolism during follicle development and granulosa cell...
- This federal Project Grant award of $234,000 from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), supports research to investigate the underlying mechanisms driving obesity and metabolic disorders in offspring of obese mothers. The research, conducted by Oregon Health & Science University, aims to leverage a mouse model to elucidate how maternal high-fat diet...
This Project Grant award of $170,640 from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) aims to investigate the role of the FGFR1 signaling pathway in the intersection between reproduction and metabolism. The primary objectives of this 5-year research project are to: (1) conduct a recall-by-genotype study and in-depth neuroendocrine and metabolic phenotyping in humans carrying rare deleterious FGF-related genetic variants, and (2) examine the FGF ligand-specific effects on FGFR1 signaling in cells related to reproduction and metabolism. This research seeks to elucidate the underlying mechanisms that govern the intricate relationship between reproduction and metabolism, with a focus on the FGFR1 pathway's potential role as a bridging mechanism.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $170.6k | 7/31/25 |