This Project Grant award, funded by the National Institute of Child Health and Human Development under the Child Health and Human Development Extramural Research program (CFDA 93.865), supports research focused on understanding the molecular mechanisms regulating uterine development. The $1,963,122 award to the University of Missouri System will be used to conduct a collaborative research project with the central hypotheses that: (1) genetic and epigenetic mechanisms govern epithelial...
This federal Project Grant award from the National Institute of Child Health and Human Development (CFDA 93.865 - Child Health and Human Development Extramural Research) provides $2,018,716 to the University of Georgia Research Foundation to conduct research on the mechanisms of uterine fluid absorption during early pregnancy. The research aims to investigate the hormonal and ionic regulation of uterine fluid movement, with a focus on understanding how disruption of ion and water channels in the...
This Project Grant award, valued at $1,474,108.00 and spanning from July 1, 2024 to March 31, 2029, is funded by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The research project aims to elucidate the cellular and molecular mechanisms underlying placenta accreta, a serious maternal condition characterized by excessive placental invasion into the uterus, often due to previous uterine...
This $675,852 Project Grant award from the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310) supports research at the University of California, San Francisco (UCSF) to gain insights into the pathophysiology of adenomyosis at single-cell resolution. The goal is to identify novel drug targets and repurpose existing compounds to address the symptoms and improve quality of life for patients with this common, understudied uterine...
This $235,803 Project Grant award from the National Institute of Child Health and Human Development under the Child Health and Human Development Extramural Research program (CFDA 93.865) supports the development of a bioengineered 3D human myometrium model to quantify the kinetics of oxytocin-induced uterine smooth muscle contractility. The research, conducted by the Texas A&M Engineering Experiment Station, aims to establish a new method for directly evaluating myometrial contractility...
This federal Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), is providing $743,287 to Oregon Health & Science University (OHSU) to conduct a multi-disciplinary research study on endocervical mucus secretion. The goal is to uncover the cellular and pathway mechanisms that regulate mucus properties in response to hormonal changes, with the long-term aim of...
This $221,448 Project Grant award from the National Institute of Child Health and Human Development (NICHD) under CFDA 93.865 - Child Health and Human Development Extramural Research program will support research to define the role of apoptosis (programmed cell death) in germline syncytium function during oogenesis (egg cell formation) at the University of North Carolina at Chapel Hill. The research aims to investigate how apoptosis regulates oocyte (egg cell) quality and health, which is...
This Federal Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), will provide $152,000.00 to North Carolina State University (NC State) for research on the role of the TET2 enzyme in regulating uterine function and fertility. The primary objectives are to determine the in vivo role of TET2 in: 1) regulation of the uterine window of receptivity, and 2) endometrial...
This $160,877 Project Grant award was provided by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The funding supports research focused on understanding the role of histone demethylase enzymes KDM3A and KDM3B in regulating epigenetic changes during primordial germ cell specification in mouse embryonic development. The research utilizes an in vitro PGC-like cell differentiation model and...
This Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), provides $658,633 to Wayne State University to conduct research on the mechanisms of the MEIG1 protein complex in mammalian spermiogenesis and fertilization. The research aims to explore how the MEIG1 complex plays a role in transporting cargo for sperm tail formation and in remodeling chromatin during...
This $584,074 Project Grant award from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) supports research to investigate the roles of the ion channel subunits Cav1.2 and Cav1.3 in uterine smooth muscle cell function, uterine peristalsis, and their relationship to fertility and the uterine disease adenomyosis. The research aims to provide a fundamental understanding of uterine peristalsis and its role in fertility, as well as gain insights into the mechanisms of adenomyosis pathogenesis. The award, with a period of performance from June 1, 2025 to February 28, 2030, is being provided to the University of Massachusetts Medical School to conduct this research.