This federal Project Grant award from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) will provide $148,000 to the University of North Texas Health Science Center at Fort Worth to explore the multilevel determinants of implementation of prenatal syphilis screening policies into clinical practice among obstetric providers. The key objectives are to: 1) Assess the multilevel determinants,...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), aims to optimize molecular polymerase chain reaction (PCR) testing for the detection of congenital syphilis. The $246,000 award, effective August 20, 2024 through July 31, 2026, will fund research to determine the optimal diagnostic specimen(s) and sampling strategy for PCR-based detection of Treponema pallidum in...
This $424,373 Project Grant, awarded by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), will support research to identify and validate transcription factors that control preeclampsia-specific gene expression programs. The project will utilize human trophoblast stem cells as a model system to elucidate the regulatory mechanisms of these "preeclampsia-driver" transcription factors...
The National Institute of Child Health and Human Development (NICHD) awarded a $424,875 Project Grant (CFDA 93.865 - Child Health and Human Development Extramural Research) to the University of Maryland, Baltimore (UMB) to investigate the role of placental serum amyloid A (SAA) isoforms in response to sub-chronic maternal inflammation and explore whether inhibition of the SAA2 isoform using small interfering RNA (siRNA) can alleviate preterm birth and adverse fetal outcomes. The project aims...
This Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the federal Child Health and Human Development Extramural Research program (CFDA 93.865), is providing $121,515 to Duke University to investigate nuclear plasticity in the human placental syncytium during pregnancy. The research aims to: 1) Determine the mechanism of nuclear subtype adaptation in the syncytiotrophoblast (STB) cell during stress, and 2) Map the unique...
This Project Grant award of $147,486, provided by the National Institute of Child Health and Human Development (NICHD) under CFDA Program 93.865 - Child Health and Human Development Extramural Research, aims to investigate the role of the placenta-brain axis in Down Syndrome (DS) development. The research, conducted by The Johns Hopkins University, will examine how increased dosage of human chromosome 21 genes, specifically APP and SOD1, impact placental function and the secretion of neuroactive...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), will provide $205,000 to the Regents of the University of California, San Francisco (UCSF) to conduct research aimed at identifying novel biomarkers for the diagnosis of syphilis in pregnancy and assessment of treatment response. The key objectives of this 2-year project include: 1) analyzing longitudinal samples from...
This federal Project Grant award for $152,816.00, provided by the National Institute of Child Health and Human Development (CFDA 93.865 - Child Health and Human Development Extramural Research), aims to investigate the link between Down's syndrome (trisomy 21) and placentation defects. The research will focus on: Identifying transcriptional differences in implantation-stage trophoblasts between trisomy 21 and euploid induced pluripotent stem cell lines through RNA-sequencing. Assessing the...
The National Institute of Child Health and Human Development (NICHD) awarded a $411,125 Project Grant (CFDA 93.865 - Child Health and Human Development Extramural Research) to Syracuse University to develop a microfluidic human placenta organoid model. The goal is to generate human trophoblast stem cells (HTSCs) from induced pluripotent stem cells and use them to create a placenta organoid system that can replicate early/mid-gestation placental development. The researchers will study the role of...
This Project Grant award of $248,999 from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), supports research to identify effective therapeutic agents for managing infection-induced preterm labor (III-PTL) and protecting against fetal inflammation. The key activities under this award include: 1) Optimizing a high-throughput screening assay to measure changes in pro-inflammatory cytokines...
This Project Grant award, valued at $167,353.00 and provided by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), supports research conducted by The University of Texas Southwestern Medical Center (UT Southwestern) to investigate the relationship between syphilis infection during pregnancy, placental pathology, and adverse neonatal outcomes. The research aims to elucidate the transcriptional dysregulation of immune cells in the placental microenvironment across a spectrum of syphilis disease and treatment. Specifically, the project will define placental histopathologic phenotypes, correlate them with treponemal burden and neonatal outcomes, and link differential placental gene expression profiles to placental abnormalities, preterm delivery, and congenital syphilis. This 5-year award will provide the awardee, Dr. Adhikari, with the training and resources to establish an independent research program focused on understanding the maternal-placental-fetal immune response to syphilis infection and its impact on pregnancy outcomes.